| Gene Information | |
|---|---|
| Gene Name | RCC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 522 |
| Protein Names | Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000179051 ) 3 ( ENSG00000281540 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9P258 |
| Gene Card | RCC2 |
| Uniprot ID | Q9P258 |
| Pfam | PF00415 |
| In ASD | no |
| Allosteric Prediction | no (-0.151207035) |
| Ortholog in Animals | Alpaca_ RCC2 ( ortholog_one2one ) Dog_ RCC2 ( ortholog_one2one ) GuineaPig_ RCC2 ( ortholog_one2one ) Macaque_ RCC2 ( ortholog_one2one ) Mouse_ Rcc2 ( ortholog_one2one ) Pig_ RCC2 ( ortholog_one2one ) Rat_ Rcc2 ( ortholog_one2one ) Rabbit_ RCC2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SERGEF, RCBTB2, RCBTB1, RCC1L, RPGR, RCCD1, HERC1, RCC1, ALS2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5GWN (X-ray 1.31A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus, nucleolus {ECO:0000305|PubMed:12429849}. Nucleus {ECO:0000269|PubMed:23388455}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23388455}. Chromosome, centromere {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:1939370, ECO:0000269|PubMed:9914378}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:1939370, ECO:0000269|PubMed:9914378}. Chromosome {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:1939370, ECO:0000269|PubMed:9914378}. Midbody {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:1939370, ECO:0000269|PubMed:9914378}. Cell membrane {ECO:0000269|PubMed:25074804}; Peripheral membrane protein {ECO:0000305|PubMed:25074804}; Cytoplasmic side {ECO:0000305|PubMed:25074804}. Note=Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex (PubMed:12919680, PubMed:1939370, PubMed:7559776, PubMed:9914378). Colocalizes with cytoplasmic microtubules in interphase cells (PubMed:23388455). Colocalizes with RAC1 at the cell membrane (PubMed:25074804). {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:1939370, ECO:0000269|PubMed:23388455, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:7559776, ECO:0000269|PubMed:9914378}. |
| Mouse PG classification | NA |
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