| Gene Information | |
|---|---|
| Gene Name | AAAS |
| Organism | Homo sapiens (Human) |
| Gene Length | 546 |
| Protein Names | Aladin (Adracalin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000094914 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NRG9 |
| Gene Card | AAAS |
| Uniprot ID | Q9NRG9 |
| Pfam | PF00400 |
| In ASD | no |
| Allosteric Prediction | no (-0.224490924) |
| Ortholog in Animals | Alpaca_ AAAS ( ortholog_one2one ) Dog_ AAAS ( ortholog_one2one ) Macaque_ AAAS ( ortholog_one2one ) Mouse_ Aaas ( ortholog_one2one ) Pig_ AAAS ( ortholog_one2one ) Rat_ Aaas ( ortholog_one2one ) Rabbit_ AAAS ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed (PubMed:11159947, PubMed:16022285). Particularly abundant in cerebellum, corpus callosum, adrenal gland, pituitary gland, gastrointestinal structures and fetal lung (PubMed:11159947). {ECO:0000269|PubMed:11159947, ECO:0000269|PubMed:16022285}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7R5K (EM 12.00A ) |
| DBSNP | rs121918549 rs13330 rs1297831120 rs121918550 |
| Subcellular location [CC] | Nucleus, nuclear pore complex {ECO:0000269|PubMed:19782045}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:26246606}. Nucleus envelope {ECO:0000269|PubMed:27754849}. Note=In metaphase cells localizes within the spindle with some accumulation around spindle poles, with the highest concentration between the centrosome and metaphase plate (PubMed:26246606). The localization to the spindle is microtubule-mediated (PubMed:26246606). {ECO:0000269|PubMed:26246606}. |
| Mouse PG classification | NA |
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