| Gene Information | |
|---|---|
| Gene Name | RBP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1857 |
| Protein Names | Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIMS-binding protein 1) (RIM-BP1) (TSPO-associated protein 1) |
| Target Name | retinol-binding protein 1 |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000114115 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O95153 |
| Gene Card | TSPOAP1 |
| Uniprot ID | O95153 |
| Pfam | PF07653; PF14604 |
| In ASD | no |
| Allosteric Prediction | no (-0.166112168) |
| Ortholog in Animals | Alpaca_ RBP1 ( ortholog_one2one ) GuineaPig_ RBP1 ( ortholog_one2one ) Mouse_ Rbp1 ( ortholog_one2one ) Pig_ RBP1 ( ortholog_one2one ) Rat_ Rbp1 ( ortholog_one2one ) |
| Ohnologs | RBP5, RBP7 |
| Paralogs | CRABP1, FABP9, FABP5, FABP12, FABP4, PMP2, RBP2, RBP5, RBP7, FABP3, FABP2, FABP6, FABP7, FABP1, CRABP2 |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in brain, pituitary gland and thymus in adults. In adult brain, highest expression found in temporal lobe and the putamen, followed by amygdala, caudate nucleus, cerebral cortex, occipital and frontal lobe. A high expression level is also observed in fetal tissues like brain, heart, kidney and thymus. {ECO:0000269|PubMed:9915832}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2072145 rs2072147 rs373894175 rs9913145 rs9905604 rs3744099 rs2680704 rs3744101 rs11079346 rs2301868 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:9915832}. Mitochondrion {ECO:0000269|PubMed:9915832}. Note=Preferentially expressed in the mitochondria in the presence of TSPO. |
| Mouse PG classification | NA |
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