| Gene Information | |
|---|---|
| Gene Name | PPIE |
| Organism | Homo sapiens (Human) |
| Gene Length | 301 |
| Protein Names | Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000084072 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9UNP9 |
| Gene Card | PPIE |
| Uniprot ID | Q9UNP9 |
| Pfam | PF00160; PF00076 |
| In ASD | no |
| Allosteric Prediction | no (-0.427430421) |
| Ortholog in Animals | Alpaca_ PPIE ( ortholog_one2one ) Dog_ PPIE ( ortholog_one2one ) GuineaPig_ PPIE ( ortholog_one2one ) Macaque_ PPIE ( ortholog_one2one ) Mouse_ Ppie ( ortholog_one2one ) Pig_ PPIE ( ortholog_one2one ) Rat_ Ppie ( ortholog_one2one ) Rabbit_ PPIE ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PPIH, PPIL4, PPIL6, CWC27, PPIB, NKTR, PPIAL4A, PPIAL4E, PPIAL4F, PPIAL4D, PPIAL4G, PPIAL4C, PPIAL4H, PPIA, PPIC, PPIG, PPID, PPWD1, PPIF, PPIL2, PPIL3, PPIL1 |
| Tissue | NA |
| Tissue Specificity | Found in all the examined tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ZMF (X-ray 1.88A ) 2CQB (NMR - ) 2KU7 (NMR - ) 2KYX (NMR - ) 2R99 (X-ray 1.61A ) 3LPY (X-ray 2.00A ) 3MDF (X-ray 1.85A ) 3UCH (X-ray 2.50A ) 5MQF (EM 5.90A ) 5YZG (EM 4.10A ) 5Z56 (EM 5.10A ) 5Z57 (EM 6.50A ) 6FF7 (EM 4.50A ) 6ICZ (EM 3.00A ) 6ID0 (EM 2.90A ) 6ID1 (EM 2.86A ) 7A5P (EM 5.00A ) 7ABI (EM 8.00A ) 7W59 (EM 3.60A ) 7W5A (EM 3.60A ) 7W5B (EM 4.30A ) 7ZEV (NMR - ) 7ZEW (NMR - ) 7ZEX (NMR - ) 7ZEY (NMR - ) 7ZEZ (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:25599396, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:8977107}. |
| Mouse PG classification | NA |
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