| Gene Information | |
|---|---|
| Gene Name | HTR2C |
| Organism | Homo sapiens (Human) |
| Gene Length | 458 |
| Protein Names | 5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C) |
| Target Name | 5-hydroxytryptamine 2 receptor |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000147246 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P28335 |
| Gene Card | HTR2C |
| Uniprot ID | P28335 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.417329357) |
| Ortholog in Animals | Alpaca_ HTR2C ( ortholog_one2one ) Alpaca_ HTR2C ( ortholog_one2many ) Dog_ HTR2C ( ortholog_one2one ) GuineaPig_ HTR2C ( ortholog_one2one ) Macaque_ HTR2C ( ortholog_one2one ) Mouse_ Htr2c ( ortholog_one2one ) Pig_ HTR2C ( ortholog_one2one ) Rabbit_ HTR2C ( ortholog_one2one ) |
| Ohnologs | HTR2A, HTR2B |
| Paralogs | HTR2A, HTR2B, HTR5A, HTR1E, HTR1B, HTR1F, HTR7, HTR6 |
| Tissue | caudate.nucleus, medulla.oblongata, putamen, nucleus.accumbens |
| Tissue Specificity | Detected in brain. {ECO:0000269|PubMed:8812491}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6BQG (X-ray 3.00A ) 6BQH (X-ray 2.70A ) 8DPF (EM 2.84A ) 8DPG (EM 3.60A ) 8DPH (EM 3.20A ) 8DPI (EM 3.40A ) |
| DBSNP | rs6318 rs781938388 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:7895773}; Multi-pass membrane protein {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:7895773}. |
| Mouse PG classification | NA |
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