| Gene Information | |
|---|---|
| Gene Name | RBM19 |
| Organism | Homo sapiens (Human) |
| Gene Length | 960 |
| Protein Names | Probable RNA-binding protein 19 (RNA-binding motif protein 19) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000122965 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y4C8 |
| Gene Card | RBM19 |
| Uniprot ID | Q9Y4C8 |
| Pfam | PF00076 |
| In ASD | no |
| Allosteric Prediction | no (-1.218848928) |
| Ortholog in Animals | Alpaca_ RBM19 ( ortholog_one2one ) Dog_ RBM19 ( ortholog_one2one ) GuineaPig_ RBM19 ( ortholog_one2one ) Macaque_ RBM19 ( ortholog_one2one ) Mouse_ Rbm19 ( ortholog_one2one ) Pig_ RBM19 ( ortholog_one2one ) Rat_ Rbm19 ( ortholog_one2one ) Rabbit_ RBM19 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RBM46, MSI2, HNRNPA1L2, HNRNPA1L3, HNRNPA1, A1CF, RBM39, RBM23, TIAL1, DAZAP1, RBMX, RBMXL1, HNRNPA0, HNRNPAB, CIRBP, RBM3, HNRNPA3, RBMY1D, RBMY1B, RBMY1A1, RBMY1J, RBMY1F, RBMY1E, MSI1, RBM47, TRNAU1AP, HNRNPA2B1, RBMXL2, RBMXL3, RBM4, RBM4B, HNRNPD, DND1, NCL, HNRNPDL, TIA1 |
| Tissue | NA |
| Tissue Specificity | Expressed in the crypts of Lieberkuhn of the intestine and in intestinal neoplasia (at protein level). {ECO:0000269|PubMed:16027046}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2DGW (NMR - ) |
| DBSNP | rs7299217 rs2290789 rs2290788 rs2290787 rs16943379 rs2075387 |
| Subcellular location [CC] | Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:16027046}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm {ECO:0000250}. Chromosome {ECO:0000250}. Note=In discrete foci distributed throughout the cytoplasm and nucleoplasm during the 4 to 8 cell stages and the morula stage, but not in the periphery of the nucleolar precursor body (NPB). During blastocyst development, becomes increasingly localized to the nucleolus and less to the cytoplasm. At the late blastocyst stage, localized predominantly in the nucleolus. Localized in the nucleolus during interphase and to the perichromosomal sheath during mitosis. Does not colocalize in the cytoplasm with GW182 in P-bodies. May translocate to the nucleolus upon early embryonic development (By similarity). Colocalizes with NPM1 during interphase. By late prophase, metaphase, anaphase and telophase, associates with the chromosome periphery. By telophase localizes to NPB. {ECO:0000250}. |
| Mouse PG classification | NA |
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