| Gene Information | |
|---|---|
| Gene Name | RBBP8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 897 |
| Protein Names | DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000101773 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q99708 |
| Gene Card | RBBP8 |
| Uniprot ID | Q99708 |
| Pfam | PF10482; PF08573 |
| In ASD | no |
| Allosteric Prediction | yes (0.172209323) |
| Ortholog in Animals | Alpaca_ RBBP8 ( ortholog_one2one ) Dog_ RBBP8 ( ortholog_one2one ) GuineaPig_ RBBP8 ( ortholog_one2one ) Macaque_ RBBP8 ( ortholog_one2one ) Mouse_ Rbbp8 ( ortholog_one2one ) Pig_ RBBP8 ( ortholog_one2one ) Rat_ Rbbp8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RBBP8NL |
| Tissue | NA |
| Tissue Specificity | Expressed in ER-positive breast cancer lines, but tends to be down-regulated ER-negative cells (at protein level). {ECO:0000269|PubMed:18171986}. |
| Pharmacological Animal Models | 0.012449(Chimpanzee);0.026576(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2L4Z (NMR - ) 4D2H (X-ray 1.90A ) 7BGF (X-ray 2.80A ) |
| DBSNP | rs373804633 rs34678569 rs1804732 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10764811, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:23623683}. Chromosome {ECO:0000269|PubMed:10764811, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:29042561}. Note=Associates with sites of DNA damage in S/G2 phase (PubMed:10764811, PubMed:25349192). Ubiquitinated RBBP8 binds to chromatin following DNA damage (PubMed:16818604). {ECO:0000269|PubMed:10764811, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:25349192}. |
| Mouse PG classification | LPG |
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