| Gene Information | |
|---|---|
| Gene Name | RBBP6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1792 |
| Protein Names | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000122257 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q7Z6E9 |
| Gene Card | RBBP6 |
| Uniprot ID | Q7Z6E9 |
| Pfam | PF08783; PF04564; PF13696 |
| In ASD | no |
| Allosteric Prediction | no (-0.232005313) |
| Ortholog in Animals | Alpaca_ RBBP6 ( ortholog_one2one ) Dog_ RBBP6 ( ortholog_one2one ) GuineaPig_ RBBP6 ( ortholog_one2one ) Macaque_ RBBP6 ( ortholog_one2one ) Mouse_ Rbbp6 ( ortholog_one2one ) Pig_ RBBP6 ( ortholog_one2one ) Rat_ Rbbp6 ( ortholog_one2one ) Rabbit_ RBBP6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ZCCHC24 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer. {ECO:0000269|PubMed:15475430}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.020200(Rat);0.083592(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2C7H (NMR - ) 2YSA (NMR - ) 2YUR (NMR - ) 3ZTG (NMR - ) 6E5X (X-ray 1.50A ) |
| DBSNP | rs16973796 rs16973840 rs3743968 |
| Subcellular location [CC] | Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with mitotic chromosomes. Colocalizes with NEK6 in the centrosome. |
| Mouse PG classification | NA |
| click here to return to the previous page | |