| Gene Information | |
|---|---|
| Gene Name | RB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 928 |
| Protein Names | Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000139687 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P06400 |
| Gene Card | RB1 |
| Uniprot ID | P06400 |
| Pfam | PF11934; PF01858; PF01857; PF08934 |
| In ASD | no |
| Allosteric Prediction | yes (1.133774575) |
| Ortholog in Animals | Alpaca_ RB1 ( ortholog_one2one ) Dog_ RB1 ( ortholog_one2one ) GuineaPig_ RB1 ( ortholog_one2one ) Macaque_ RB1 ( ortholog_one2one ) Mouse_ Rb1 ( ortholog_one2one ) Pig_ RB1 ( ortholog_one2one ) Rat_ Rb1 ( ortholog_one2one ) Rabbit_ RB1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RBL1, RBL2 |
| Tissue | NA |
| Tissue Specificity | Expressed in the retina. Expressed in foreskin keratinocytes (at protein level) (PubMed:20940255). {ECO:0000269|PubMed:20940255}. |
| Pharmacological Animal Models | 0.062724(Chimpanzee);0.050990(Mouse);0.011735(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1AD6 (X-ray 2.30A ) 1GH6 (X-ray 3.20A ) 1GUX (X-ray 1.85A ) 1H25 (X-ray 2.50A ) 1N4M (X-ray 2.20A ) 1O9K (X-ray 2.60A ) 1PJM (X-ray 2.50A ) 2AZE (X-ray 2.55A ) 2QDJ (X-ray 2.00A ) 2R7G (X-ray 1.67A ) 3N5U (X-ray 3.20A ) 3POM (X-ray 2.50A ) 4CRI (X-ray 2.35A ) 4ELJ (X-ray 2.70A ) 4ELL (X-ray 1.98A ) |
| DBSNP | rs3092900 rs3092902 rs200844292 rs767011440 rs4151534 rs4151539 rs1948534047 rs1050717570 rs137853292 rs3092895 rs137853294 rs3092903 rs137853296 rs3092905 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:20940255}. Note=During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization. {ECO:0000269|PubMed:20940255}. |
| Mouse PG classification | NA |
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