| Gene Information | |
|---|---|
| Gene Name | ADCY10 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1610 |
| Protein Names | Adenylate cyclase type 10 (EC 4.6.1.1) (AH-related protein) (Adenylate cyclase homolog) (Germ cell soluble adenylyl cyclase) (hsAC) (sAC) (Testicular soluble adenylyl cyclase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000143199 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q96PN6 |
| Gene Card | ADCY10 |
| Uniprot ID | Q96PN6 |
| Pfam | PF00211 |
| In ASD | yes |
| Allosteric Prediction | yes (1.10535536) |
| Ortholog in Animals | Alpaca_ ADCY10 ( ortholog_one2one ) Dog_ ADCY10 ( ortholog_one2one ) GuineaPig_ ADCY10 ( ortholog_one2one ) Macaque_ ADCY10 ( ortholog_one2one ) Mouse_ Adcy10 ( ortholog_one2one ) Pig_ ADCY10 ( ortholog_one2one ) Rat_ Adcy10 ( ortholog_one2one ) Rabbit_ ADCY10 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | testis |
| Tissue Specificity | Detected in airway epithelial cells and testis (at protein level) (PubMed:17591988). Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunum and ileum. Very low level of expression in bone. {ECO:0000269|PubMed:11932268, ECO:0000269|PubMed:15659711, ECO:0000269|PubMed:17591988}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4CLF (X-ray 1.70A ) 4CLK (X-ray 2.20A ) 4CLL (X-ray 1.70A ) 4CLP (X-ray 1.90A ) 4CLS (X-ray 1.85A ) 4CLT (X-ray 1.95A ) 4CLU (X-ray 1.90A ) 4CLW (X-ray 2.15A ) 4CLY (X-ray 2.05A ) 4CLZ (X-ray 1.90A ) 4CM0 (X-ray 3.20A ) 4CM2 (X-ray 1.80A ) 4OYA (X-ray 2.03A ) 4OYB (X-ray 1.70A ) 4OYI (X-ray 1.70A ) 4OYM (X-ray 1.70A ) 4OYO (X-ray 1.75A ) 4OYP (X-ray 2.28A ) 4OYW (X-ray 1.70A ) 4OYX (X-ray 1.89A ) 4OYZ (X-ray 1.74A ) 4OZ2 (X-ray 2.10A ) 4OZ3 (X-ray 1.70A ) 4UST (X-ray 1.90A ) 4USU (X-ray 1.95A ) 4USV (X-ray 2.00A ) 4USW (X-ray 2.05A ) 5D0R (X-ray 2.24A ) 5IV3 (X-ray 1.86A ) 5IV4 (X-ray 1.79A ) 7OVD (X-ray 2.20A ) |
| DBSNP | rs16859886 rs2071921 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15659711}; Peripheral membrane protein {ECO:0000269|PubMed:15659711}; Cytoplasmic side {ECO:0000269|PubMed:15659711}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12475901, ECO:0000269|PubMed:15659711}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12475901, ECO:0000269|PubMed:15659711}. Nucleus {ECO:0000269|PubMed:12475901, ECO:0000269|PubMed:15659711}. Cell projection, cilium {ECO:0000269|PubMed:17591988}. Cytoplasm {ECO:0000269|PubMed:12475901}. Mitochondrion {ECO:0000269|PubMed:12475901}. Note=Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin. {ECO:0000269|PubMed:12475901, ECO:0000269|PubMed:15659711}. |
| Mouse PG classification | LPG |
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