| Gene Information | |
|---|---|
| Gene Name | RASSF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 344 |
| Protein Names | Ras association domain-containing protein 1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000068028 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9NS23 |
| Gene Card | RASSF1 |
| Uniprot ID | Q9NS23 |
| Pfam | PF16517; PF00788 |
| In ASD | no |
| Allosteric Prediction | yes (0.12561014) |
| Ortholog in Animals | Alpaca_ RASSF1 ( ortholog_one2one ) Dog_ RASSF1 ( ortholog_one2one ) GuineaPig_ RASSF1 ( ortholog_one2one ) Macaque_ RASSF1 ( ortholog_one2one ) Mouse_ Rassf1 ( ortholog_one2one ) Pig_ RASSF1 ( ortholog_one2one ) Rat_ Rassf1 ( ortholog_one2one ) |
| Ohnologs | RASSF3 |
| Paralogs | RASSF6, RASSF4, RASSF3, RASSF5, RASSF2 |
| Tissue | NA |
| Tissue Specificity | Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells. {ECO:0000269|PubMed:10888881, ECO:0000269|PubMed:11333291}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001516(Rat);0.0375(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2KZU (NMR - ) |
| DBSNP | rs4688725 rs201618726 rs76335415 rs934370004 rs2073498 rs12488879 rs782655006 |
| Subcellular location [CC] | [Isoform A]: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. Colocalizes with MDM2 in the nucleus.; [Isoform C]: Nucleus. Note=Predominantly nuclear. |
| Mouse PG classification | NA |
| click here to return to the previous page | |