| Gene Information | |
|---|---|
| Gene Name | PYCR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 320 |
| Protein Names | Pyrroline-5-carboxylate reductase 2 (P5C reductase 2) (P5CR 2) (EC 1.5.1.2) |
| Target Name | pyrroline-5-carboxylate reductase 2 |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000143811 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q96C36 |
| Gene Card | PYCR2 |
| Uniprot ID | Q96C36 |
| Pfam | PF03807; PF14748 |
| In ASD | no |
| Allosteric Prediction | no (-0.224181932) |
| Ortholog in Animals | Alpaca_ PYCR2 ( ortholog_one2one ) Dog_ PYCR2 ( ortholog_one2one ) GuineaPig_ PYCR2 ( ortholog_one2one ) Mouse_ Pycr2 ( ortholog_one2one ) Pig_ PYCR2 ( ortholog_one2one ) Rat_ Pycr2 ( ortholog_one2one ) Rabbit_ PYCR2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PYCR1, PYCR3, NOXRED1 |
| Tissue | NA |
| Tissue Specificity | Detected in erythrocytes (at protein level) (PubMed:2722838, PubMed:6894153). Expressed in fetal brain (PubMed:25865492). {ECO:0000269|PubMed:25865492, ECO:0000269|PubMed:2722838, ECO:0000269|PubMed:6894153}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001899(Rat);0.044444(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6LHM (X-ray 3.40A ) |
| DBSNP | rs372781135 rs876657403 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:2722838}. Mitochondrion {ECO:0000269|PubMed:23024808, ECO:0000269|PubMed:25865492}. |
| Mouse PG classification | NA |
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