| Gene Information | |
|---|---|
| Gene Name | RASGRP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 797 |
| Protein Names | RAS guanyl-releasing protein 1 (Calcium and DAG-regulated guanine nucleotide exchange factor II) (CalDAG-GEFII) (Ras guanyl-releasing protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000172575 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O95267 |
| Gene Card | RASGRP1 |
| Uniprot ID | O95267 |
| Pfam | PF00130; PF13405; PF00617; PF00618 |
| In ASD | no |
| Allosteric Prediction | yes (0.699893441) |
| Ortholog in Animals | Alpaca_ RASGRP1 ( ortholog_one2one ) Dog_ RASGRP1 ( ortholog_one2one ) GuineaPig_ RASGRP1 ( ortholog_one2one ) Macaque_ RASGRP1 ( ortholog_one2one ) Mouse_ Rasgrp1 ( ortholog_one2one ) Pig_ RASGRP1 ( ortholog_one2one ) Rat_ Rasgrp1 ( ortholog_one2one ) Rabbit_ RASGRP1 ( ortholog_one2one ) |
| Ohnologs | RASGRP4, RASGRP2, RASGRP3 |
| Paralogs | RALGDS, RASGEF1A, RASGRF2, RASGRP3, SOS2, RAPGEF3, RAPGEF6, RASGRF1, RAPGEF2, RGL1, RAPGEF1, RASGEF1B, RASGRP2, RGL2, SOS1, RGL3, RALGPS1, RALGPS2, RAPGEF4, RGL4, RASGRP4, RAPGEFL1, RAPGEF5, RASGEF1C |
| Tissue | cerebellum, cerebellar.hemisphere |
| Tissue Specificity | Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level). Expressed in NK cells (at protein level) (PubMed:19933860). {ECO:0000269|PubMed:10807788, ECO:0000269|PubMed:17878389, ECO:0000269|PubMed:19933860, ECO:0000269|PubMed:9789079}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4L9M (X-ray 3.00A ) 4L9U (X-ray 1.60A ) |
| DBSNP | rs1595848141 |
| Subcellular location [CC] | Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Found both in the cytosol and associated with membranes. Relocalization to the cell membrane upon activation is F-actin-dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor. Localizes to somata and dendrites but not to axons of hippocampal pyramidal cells (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |