| Gene Information | |
|---|---|
| Gene Name | RASGRF2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1237 |
| Protein Names | Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000113319 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O14827 |
| Gene Card | RASGRF2 |
| Uniprot ID | O14827 |
| Pfam | PF00169; PF00617; PF00618; PF00621 |
| In ASD | no |
| Allosteric Prediction | yes (0.660991417) |
| Ortholog in Animals | Alpaca_ RASGRF2 ( ortholog_one2one ) Dog_ RASGRF2 ( ortholog_one2one ) GuineaPig_ RASGRF2 ( ortholog_one2one ) Macaque_ RASGRF2 ( ortholog_one2one ) Mouse_ Rasgrf2 ( ortholog_one2one ) Pig_ RASGRF2 ( ortholog_one2one ) Rat_ AABR07007642.1 ( ortholog_one2one ) Rabbit_ RASGRF2 ( ortholog_one2one ) |
| Ohnologs | RASGRF1 |
| Paralogs | RALGDS, RASGEF1A, RASGRP3, SOS2, RAPGEF3, RAPGEF6, RASGRF1, RAPGEF2, RGL1, RAPGEF1, RASGEF1B, RASGRP2, RGL2, SOS1, RGL3, RALGPS1, RALGPS2, RAPGEF4, RGL4, RASGRP4, RAPGEFL1, RAPGEF5, RASGRP1, RASGEF1C |
| Tissue | NA |
| Tissue Specificity | Widely expressed with higher expression in brain, followed by heart, lung, pancreas and kidney. Detected in placenta. Expressed in brain and lung (at protein level). {ECO:0000269|PubMed:10373510, ECO:0000269|PubMed:11856323}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs779986744 rs1466151520 rs16878472 |
| Subcellular location [CC] | Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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