| Gene Information | |
|---|---|
| Gene Name | RARA |
| Organism | Homo sapiens (Human) |
| Gene Length | 462 |
| Protein Names | Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1) |
| Target Name | retinoic acid receptor alpha |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000131759 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P10276 |
| Gene Card | RARA |
| Uniprot ID | P10276 |
| Pfam | PF00104; PF00105 |
| In ASD | yes |
| Allosteric Prediction | yes (1.377801242) |
| Ortholog in Animals | Alpaca_ RARA ( ortholog_one2one ) Dog_ RARA ( ortholog_one2one ) GuineaPig_ RARA ( ortholog_one2one ) Macaque_ RARA ( ortholog_one2one ) Mouse_ Rara ( ortholog_one2one ) Pig_ RARA ( ortholog_one2one ) Rat_ Rara ( ortholog_one2one ) Rabbit_ RARA ( ortholog_one2one ) |
| Ohnologs | RARB, PPARG, RARG |
| Paralogs | NR1H4, VDR, RARG, NR1D2, PPARD, NR1H2, RORC, THRB, NR1D1, NR1H3, NR1I2, PPARG, NR1I3, RARB, RORB, PPARA, RORA, THRA |
| Tissue | NA |
| Tissue Specificity | Expressed in monocytes. {ECO:0000269|PubMed:26463675}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.105514(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1DKF (X-ray 2.50A ) 1DSZ (X-ray 1.70A ) 3A9E (X-ray 2.75A ) 3KMR (X-ray 1.80A ) 3KMZ (X-ray 2.10A ) 4DQM (X-ray 2.75A ) 5K13 (X-ray 1.85A ) 6XWG (X-ray 2.40A ) 7AOS (X-ray 2.55A ) 7APO (X-ray 2.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:19850744, ECO:0000269|PubMed:28167758}. Cytoplasm {ECO:0000269|PubMed:19850744, ECO:0000269|PubMed:28167758}. Note=Nuclear localization depends on ligand binding, phosphorylation and sumoylation (PubMed:19850744). Translocation to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation (By similarity). Increased nuclear localization upon pulsatile shear stress (PubMed:28167758). {ECO:0000250|UniProtKB:P11416, ECO:0000269|PubMed:19850744, ECO:0000269|PubMed:28167758}. |
| Mouse PG classification | LPG |
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