| Gene Information | |
|---|---|
| Gene Name | RAPL |
| Organism | Homo sapiens (Human) |
| Gene Length | 418 |
| Protein Names | Ras association domain-containing protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8WWW0 |
| Gene Card | RASSF5 |
| Uniprot ID | Q8WWW0 |
| Pfam | PF00130; PF16517; PF00788 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors. {ECO:0000269|PubMed:11965544, ECO:0000269|PubMed:12676952}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001657(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4LGD (X-ray 3.05A ) 4OH8 (X-ray 2.28A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A. |
| Mouse PG classification | NA |
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