| Gene Information | |
|---|---|
| Gene Name | RAPGEF5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 580 |
| Protein Names | Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (Related to Epac) (Repac) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000136237 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q92565 |
| Gene Card | RAPGEF5 |
| Uniprot ID | Q92565 |
| Pfam | PF00617; PF00618 |
| In ASD | no |
| Allosteric Prediction | yes (0.281074908) |
| Ortholog in Animals | Alpaca_ RAPGEF5 ( ortholog_one2one ) Dog_ RAPGEF5 ( ortholog_one2one ) GuineaPig_ RAPGEF5 ( ortholog_one2one ) Macaque_ RAPGEF5 ( ortholog_one2one ) Mouse_ Rapgef5 ( ortholog_one2one ) Rat_ Rapgef5 ( ortholog_one2one ) Rabbit_ RAPGEF5 ( ortholog_one2one ) |
| Ohnologs | RAPGEF3, RAPGEFL1, RAPGEF4 |
| Paralogs | RALGDS, RASGEF1A, RASGRF2, RASGRP3, SOS2, RAPGEF3, RAPGEF6, RASGRF1, RAPGEF2, RGL1, RAPGEF1, RASGEF1B, RASGRP2, RGL2, SOS1, RGL3, RALGPS1, RALGPS2, RAPGEF4, RGL4, RASGRP4, RAPGEFL1, RASGRP1, RASGEF1C |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels in brain. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1WGY (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus. |
| Mouse PG classification | NA |
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