| Gene Information | |
|---|---|
| Gene Name | STK24 |
| Organism | Homo sapiens (Human) |
| Gene Length | 443 |
| Protein Names | Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] |
| Target Name | serine/threonine-protein kinase 24 |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000102572 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y6E0 |
| Gene Card | STK24 |
| Uniprot ID | Q9Y6E0 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.083896988) |
| Ortholog in Animals | Alpaca_ STK24 ( ortholog_one2one ) Dog_ STK24 ( ortholog_one2one ) GuineaPig_ STK24 ( ortholog_one2one ) Macaque_ STK24 ( ortholog_one2one ) Mouse_ Stk24 ( ortholog_one2one ) Pig_ STK24 ( ortholog_one2one ) Rat_ Stk24 ( ortholog_one2one ) Rabbit_ STK24 ( ortholog_one2one ) |
| Ohnologs | STK26, STK25 |
| Paralogs | PAK5, PAK6, PAK4, SBK2, STK39, MAP4K1, PAK2, PAK1, PAK3, MINK1, TNIK, MAP4K5, SLK, MAP3K14, MAP3K19, STRADB, STK4, MAP3K1, TAOK2, MAP4K3, NRK, STRADA, MAP2K3, STK10, MAP2K6, STK26, TAOK3, TAOK1, MAP3K8, MAP4K2, OXSR1, STK3, NEK4, MAP4K4, STK25 |
| Tissue | NA |
| Tissue Specificity | Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex. |
| Pharmacological Animal Models | 0.122339(Chimpanzee);0.065239(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3A7F (X-ray 1.55A ) 3A7G (X-ray 2.00A ) 3A7H (X-ray 1.96A ) 3A7I (X-ray 1.45A ) 3A7J (X-ray 1.50A ) 3CKW (X-ray 1.96A ) 3CKX (X-ray 2.70A ) 3ZHP (X-ray 2.90A ) 4O27 (X-ray 3.18A ) 4QML (X-ray 1.88A ) 4QMM (X-ray 1.85A ) 4QMN (X-ray 2.09A ) 4QMO (X-ray 1.90A ) 4QMP (X-ray 2.00A ) 4QMQ (X-ray 1.77A ) 4QMS (X-ray 1.88A ) 4QMT (X-ray 1.50A ) 4QMU (X-ray 1.55A ) 4QMV (X-ray 2.40A ) 4QMW (X-ray 1.60A ) 4QMX (X-ray 1.88A ) 4QMY (X-ray 1.88A ) 4QMZ (X-ray 1.88A ) 4QNA (X-ray 1.85A ) 4QO9 (X-ray 2.20A ) 4U8Z (X-ray 1.63A ) 4W8D (X-ray 1.77A ) 4W8E (X-ray 1.79A ) 7B30 (X-ray 2.10A ) 7B31 (X-ray 1.80A ) 7B32 (X-ray 1.75A ) 7B33 (X-ray 1.90A ) 7B34 (X-ray 2.10A ) 7B35 (X-ray 2.40A ) |
| DBSNP | rs55953606 rs55897869 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane. |
| Mouse PG classification | NA |
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