| Gene Information | |
|---|---|
| Gene Name | RAPGEF4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1011 |
| Protein Names | Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) |
| Target Name | rap guanine nucleotide exchange factor 4 |
| Target Type | Literature-reported target |
| Gene Age | 645 ( ENSG00000091428 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8WZA2 |
| Gene Card | RAPGEF4 |
| Uniprot ID | Q8WZA2 |
| Pfam | PF00027; PF00610; PF00617; PF00618 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000155927) |
| Ortholog in Animals | Alpaca_ RAPGEF4 ( ortholog_one2one ) Dog_ RAPGEF4 ( ortholog_one2one ) GuineaPig_ RAPGEF4 ( ortholog_one2one ) Macaque_ RAPGEF4 ( ortholog_one2one ) Mouse_ Rapgef4 ( ortholog_one2one ) Pig_ RAPGEF4 ( ortholog_one2one ) Rat_ Rapgef4 ( ortholog_one2one ) Rabbit_ RAPGEF4 ( ortholog_one2one ) |
| Ohnologs | RAPGEF3, RAPGEF5 |
| Paralogs | RALGDS, RASGEF1A, RASGRF2, RASGRP3, SOS2, RAPGEF3, RAPGEF6, RASGRF1, RAPGEF2, RGL1, RAPGEF1, RASGEF1B, RASGRP2, RGL2, SOS1, RGL3, RALGPS1, RALGPS2, RGL4, RASGRP4, RAPGEFL1, RAPGEF5, RASGRP1, RASGEF1C |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
| Mouse PG classification | NA |
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