| Gene Information | |
|---|---|
| Gene Name | NSUN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 767 |
| Protein Names | RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000037474 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q08J23 |
| Gene Card | NSUN2 |
| Uniprot ID | Q08J23 |
| Pfam | PF01189 |
| In ASD | no |
| Allosteric Prediction | no (-1.00018022) |
| Ortholog in Animals | Alpaca_ NSUN2 ( ortholog_one2one ) Dog_ NSUN2 ( ortholog_one2one ) GuineaPig_ NSUN2 ( ortholog_one2one ) Macaque_ NSUN2 ( ortholog_one2one ) Mouse_ Nsun2 ( ortholog_one2one ) Pig_ NSUN2 ( ortholog_one2one ) Rat_ Nsun2 ( ortholog_one2one ) Rabbit_ NSUN2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NSUN4, NSUN3 |
| Tissue | NA |
| Tissue Specificity | Expressed in adult and fetal brain and in lymphoblastoid cells. {ECO:0000269|PubMed:22541559}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001899(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2303708 rs587776908 |
| Subcellular location [CC] | Nucleus, nucleolus {ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:17215513, ECO:0000269|PubMed:31276587}. Cytoplasm {ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:31276587}. Mitochondrion {ECO:0000269|PubMed:31276587, ECO:0000269|PubMed:31287866}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19596847}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:Q1HFZ0}. Note=Concentrated in the nucleolus during interphase and translocates to the spindle during mitosis as an RNA-protein complex that includes 18S ribosomal RNA (PubMed:19596847). In testis, localizes to the chromatoid body (By similarity). {ECO:0000250|UniProtKB:Q1HFZ0, ECO:0000269|PubMed:19596847}. |
| Mouse PG classification | NA |
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