| Gene Information | |
|---|---|
| Gene Name | RELA |
| Organism | Homo sapiens (Human) |
| Gene Length | 551 |
| Protein Names | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) |
| Target Name | transcription factor p65 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000173039 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q04206 |
| Gene Card | RELA |
| Uniprot ID | Q04206 |
| Pfam | PF16179; PF00554 |
| In ASD | no |
| Allosteric Prediction | yes (1.323458205) |
| Ortholog in Animals | Alpaca_ RELA ( ortholog_one2one ) Dog_ RELA ( ortholog_one2one ) GuineaPig_ RELA ( ortholog_one2one ) Macaque_ RELA ( ortholog_one2one ) Mouse_ Rela ( ortholog_one2one ) Pig_ RELA ( ortholog_one2one ) Rat_ Rela ( ortholog_one2one ) |
| Ohnologs | RELB, REL |
| Paralogs | REL, RELB, NFKB1, NFKB2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1NFI (X-ray 2.70A ) 2LSP (NMR - ) 2O61 (X-ray 2.80A ) 3GUT (X-ray 3.59A ) 3QXY (X-ray 2.09A ) 3RC0 (X-ray 2.19A ) 4KV1 (X-ray 1.50A ) 4KV4 (X-ray 2.00A ) 5U4K (NMR - ) 5URN (NMR - ) 6NV2 (X-ray 1.13A ) 6QHL (X-ray 1.20A ) 6QHM (X-ray 1.25A ) 6YOW (X-ray 1.23A ) 6YOX (X-ray 2.05A ) 6YOY (X-ray 1.80A ) 6YP2 (X-ray 1.80A ) 6YP3 (X-ray 1.80A ) 6YP8 (X-ray 1.80A ) 6YPL (X-ray 1.80A ) 6YPY (X-ray 1.40A ) 6YQ2 (X-ray 1.40A ) 7BI3 (X-ray 1.20A ) 7BIQ (X-ray 1.20A ) 7BIW (X-ray 1.20A ) 7BIY (X-ray 1.80A ) 7BJB (X-ray 1.80A ) 7BJF (X-ray 1.40A ) 7BJL (X-ray 1.40A ) 7BJW (X-ray 1.40A ) 7BKH (X-ray 1.40A ) 7LET (X-ray 2.40A ) 7LEU (X-ray 2.82A ) 7LF4 (X-ray 2.85A ) 7NJ9 (X-ray 1.40A ) 7NJB (X-ray 1.40A ) 7NK3 (X-ray 1.40A ) 7NK5 (X-ray 1.40A ) 7NLA (X-ray 1.40A ) 7NLE (X-ray 1.40A ) 7NM1 (X-ray 1.40A ) 7NM3 (X-ray 1.40A ) 7NM9 (X-ray 1.70A ) 7NMH (X-ray 1.40A ) 7NQP (X-ray 1.24A ) 7NR7 (X-ray 1.40A ) 7NSV (X-ray 1.33A ) 7NV4 (X-ray 1.20A ) 7NVI (X-ray 1.20A ) 7NWS (X-ray 1.20A ) 7NXS (X-ray 1.20A ) 7NXT (X-ray 1.20A ) 7NXW (X-ray 1.20A ) 7NXY (X-ray 1.20A ) 7NY4 (X-ray 1.40A ) 7NYE (X-ray 1.40A ) 7NYF (X-ray 1.40A ) 7NYG (X-ray 1.40A ) 7NZ6 (X-ray 1.40A ) 7NZG (X-ray 1.40A ) 7NZK (X-ray 1.40A ) 7NZV (X-ray 1.40A ) 7O34 (X-ray 1.20A ) 7O3A (X-ray 1.20A ) 7O3F (X-ray 1.40A ) 7O3P (X-ray 1.40A ) 7O3Q (X-ray 1.80A ) 7O3R (X-ray 1.80A ) 7O3S (X-ray 2.00A ) 7O57 (X-ray 1.40A ) 7O59 (X-ray 1.20A ) 7O5A (X-ray 1.80A ) 7O5C (X-ray 1.80A ) 7O5D (X-ray 1.80A ) 7O5F (X-ray 1.80A ) 7O5G (X-ray 1.80A ) 7O5O (X-ray 1.80A ) 7O5P (X-ray 1.80A ) 7O5S (X-ray 1.80A ) 7O5U (X-ray 1.80A ) 7O5X (X-ray 1.80A ) 7O6F (X-ray 2.00A ) 7O6G (X-ray 1.80A ) 7O6I (X-ray 1.80A ) 7O6J (X-ray 1.40A ) 7O6K (X-ray 1.40A ) 7O6M (X-ray 1.40A ) 7O6O (X-ray 1.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:1493333, ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:20547752}. Cytoplasm {ECO:0000269|PubMed:1493333, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:24807716, ECO:0000269|PubMed:27736973}. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B) (PubMed:1493333). Colocalized with DDX1 in the nucleus upon TNF-alpha induction (PubMed:19058135). Colocalizes with GFI1 in the nucleus after LPS stimulation (PubMed:20547752). Translocation to the nucleus is impaired in L.monocytogenes infection (PubMed:20855622). {ECO:0000269|PubMed:1493333, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:20855622}. |
| Mouse PG classification | NA |
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