| Gene Information | |
|---|---|
| Gene Name | RAN |
| Organism | Homo sapiens (Human) |
| Gene Length | 216 |
| Protein Names | GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein) |
| Target Name | gtp-binding nuclear protein ran |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000132341 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P62826 |
| Gene Card | RAN |
| Uniprot ID | P62826 |
| Pfam | PF00071 |
| In ASD | no |
| Allosteric Prediction | yes (0.752729845) |
| Ortholog in Animals | Alpaca_ RAN ( ortholog_one2one ) Alpaca_ RAN ( ortholog_one2many ) Dog_ RAN ( ortholog_one2many ) Macaque_ RAN ( ortholog_one2one ) Mouse_ Rasl2-9 ( ortholog_one2many ) Mouse_ 1700009N14Rik ( ortholog_one2many ) Mouse_ Ran ( ortholog_one2many ) Pig_ RAN ( ortholog_one2one ) Rat_ Ran ( ortholog_one2many ) Rat_ Rasl2-9 ( ortholog_one2many ) Rat_ RGD1306195 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in a variety of tissues. {ECO:0000269|PubMed:2108320}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001225(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1I2M (X-ray 1.76A ) 1IBR (X-ray 2.30A ) 1K5D (X-ray 2.70A ) 1K5G (X-ray 3.10A ) 1QBK (X-ray 3.00A ) 1RRP (X-ray 2.96A ) 2MMC (NMR - ) 2MMG (NMR - ) 2N1B (NMR - ) 3CH5 (X-ray 2.10A ) 3EA5 (X-ray 2.50A ) 3GJ0 (X-ray 1.48A ) 3GJ3 (X-ray 1.79A ) 3GJ4 (X-ray 2.15A ) 3GJ5 (X-ray 1.79A ) 3GJ6 (X-ray 2.70A ) 3GJ7 (X-ray 1.93A ) 3GJ8 (X-ray 1.82A ) 3GJX (X-ray 2.50A ) 3NBY (X-ray 3.42A ) 3NBZ (X-ray 2.80A ) 3NC0 (X-ray 2.90A ) 3NC1 (X-ray 3.35A ) 3ZJY (X-ray 3.60A ) 4C0Q (X-ray 3.42A ) 4GMX (X-ray 2.10A ) 4GPT (X-ray 2.22A ) 4HAT (X-ray 1.78A ) 4HAU (X-ray 2.00A ) 4HAV (X-ray 2.00A ) 4HAW (X-ray 1.90A ) 4HAX (X-ray 2.28A ) 4HAY (X-ray 2.30A ) 4HAZ (X-ray 1.90A ) 4HB0 (X-ray 2.20A ) 4HB2 (X-ray 1.80A ) 4HB3 (X-ray 2.80A ) 4HB4 (X-ray 2.05A ) 4OL0 (X-ray 2.90A ) 4WVF (X-ray 1.80A ) 5CIQ (X-ray 1.65A ) 5CIT (X-ray 1.75A ) 5CIW (X-ray 1.75A ) 5CJ2 (X-ray 1.75A ) 5CLL (X-ray 2.45A ) 5CLQ (X-ray 3.20A ) 5DH9 (X-ray 2.55A ) 5DHA (X-ray 2.95A ) 5DHF (X-ray 2.29A ) 5DI9 (X-ray 2.28A ) 5DIF (X-ray 2.09A ) 5DIS (X-ray 2.85A ) 5DLQ (X-ray 3.20A ) 5FYQ (X-ray 3.00A ) 5JLJ (X-ray 2.50A ) 5UWH (X-ray 2.26A ) 5UWI (X-ray 2.14A ) 5UWJ (X-ray 2.22A ) 5UWO (X-ray 2.35A ) 5UWP (X-ray 2.05A ) 5UWQ (X-ray 2.28A ) 5UWR (X-ray 2.24A ) 5UWS (X-ray 2.40A ) 5UWT (X-ray 2.34A ) 5UWU (X-ray 2.24A ) 5UWW (X-ray 2.15A ) 5YRO (X-ray 2.40A ) 5YST (X-ray 2.04A ) 5YSU (X-ray 2.30A ) 5YTB (X-ray 2.30A ) 5ZPU (X-ray 2.60A ) 6A38 (X-ray 2.69A ) 6A3A (X-ray 2.30A ) 6A3B (X-ray 2.51A ) 6A3C (X-ray 2.35A ) 6A3E (X-ray 2.70A ) 6CIT (X-ray 2.03A ) 6KFT (X-ray 2.51A ) 6LQ9 (X-ray 2.50A ) 6M60 (X-ray 2.17A ) 6M6X (X-ray 2.88A ) 6Q82 (X-ray 2.99A ) 6Q84 (X-ray 3.70A ) 6TVO (X-ray 3.20A ) 6X2M (X-ray 2.35A ) 6X2O (X-ray 2.55A ) 6X2P (X-ray 2.40A ) 6X2R (X-ray 2.30A ) 6X2S (X-ray 2.50A ) 6X2U (X-ray 2.20A ) 6X2V (X-ray 2.82A ) 6X2W (X-ray 3.00A ) 6X2X (X-ray 2.46A ) 6X2Y (X-ray 2.30A ) 6XJP (X-ray 2.80A ) 6XJR (X-ray 1.94A ) 6XJS (X-ray 1.94A ) 6XJT (X-ray 2.41A ) 6XJU (X-ray 2.19A ) 7B51 (X-ray 2.58A ) 7CND (X-ray 1.80A ) 7DBG (X-ray 2.06A ) 7L5E (X-ray 1.94A ) 7MNP (X-ray 2.05A ) 7MNQ (X-ray 2.05A ) 7MNR (X-ray 1.80A ) 7MNS (X-ray 2.10A ) 7MNT (X-ray 2.45A ) 7MNU (X-ray 2.00A ) 7MNV (X-ray 1.80A ) 7MNW (X-ray 2.40A ) 7MNX (X-ray 2.40A ) 7MNY (X-ray 2.70A ) 7MNZ (X-ray 2.35A ) 7MO0 (X-ray 2.45A ) 7MO1 (X-ray 1.60A ) 7MO2 (X-ray 1.65A ) 7MO3 (X-ray 2.05A ) 7MO4 (X-ray 2.40A ) 7MO5 (X-ray 1.55A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10679025, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:1961752, ECO:0000269|PubMed:19753112, ECO:0000269|PubMed:31075303, ECO:0000269|PubMed:8421051, ECO:0000269|PubMed:8896452, ECO:0000269|PubMed:9351834, ECO:0000269|PubMed:9822603}. Nucleus envelope {ECO:0000269|PubMed:8896452, ECO:0000269|PubMed:9822603}. Cytoplasm, cytosol {ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:8276887}. Cytoplasm {ECO:0000269|PubMed:10679025, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:9822603}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Predominantly nuclear during interphase (PubMed:8421051, PubMed:12194828, PubMed:10679025). Becomes dispersed throughout the cytoplasm during mitosis (PubMed:8421051, PubMed:12194828). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269|PubMed:10679025, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:8421051}. |
| Mouse PG classification | NA |
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