| Gene Information | |
|---|---|
| Gene Name | RAMP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 175 |
| Protein Names | Receptor activity-modifying protein 2 (Calcitonin-receptor-like receptor activity-modifying protein 2) (CRLR activity-modifying protein 2) |
| Target Name | receptor activity-modifying protein 2 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000131477 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O60895 |
| Gene Card | RAMP2 |
| Uniprot ID | O60895 |
| Pfam | PF04901 |
| In ASD | no |
| Allosteric Prediction | yes (0.277783555) |
| Ortholog in Animals | Alpaca_ RAMP2 ( ortholog_one2one ) Dog_ VPS25 ( ortholog_one2one ) GuineaPig_ RAMP2 ( ortholog_one2one ) Macaque_ RAMP2 ( ortholog_one2one ) Mouse_ Ramp2 ( ortholog_one2one ) Pig_ RAMP2 ( ortholog_one2one ) Rabbit_ RAMP2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RAMP3, RAMP1 |
| Tissue | NA |
| Tissue Specificity | Strongly expressed in lung, breast, immune system and fetal tissues. {ECO:0000269|PubMed:9620797}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.163861(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2XVT (X-ray 2.05A ) 3AQE (X-ray 2.00A ) 3AQF (X-ray 2.60A ) 4RWF (X-ray 1.76A ) 6UUN (EM 3.00A ) 6V2E (X-ray 1.83A ) 7TYH (EM 3.30A ) 7TYX (EM 2.55A ) 7TYY (EM 3.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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