| Gene Information | |
|---|---|
| Gene Name | RALGPS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 557 |
| Protein Names | Ras-specific guanine nucleotide-releasing factor RalGPS1 (Ral GEF with PH domain and SH3-binding motif 1) (Ral guanine nucleotide exchange factor 2) (RalGEF 2) (RalA exchange factor RalGPS1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000136828 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q5JS13 |
| Gene Card | RALGPS1 |
| Uniprot ID | Q5JS13 |
| Pfam | PF00169; PF00617 |
| In ASD | no |
| Allosteric Prediction | no (-1.234876752) |
| Ortholog in Animals | Alpaca_ RALGPS1 ( ortholog_one2one ) Dog_ RALGPS1 ( ortholog_one2one ) GuineaPig_ RALGPS1 ( ortholog_one2one ) Macaque_ RALGPS1 ( ortholog_one2one ) Mouse_ Ralgps1 ( ortholog_one2one ) Pig_ RALGPS1 ( ortholog_one2one ) Rat_ Ralgps1 ( ortholog_one2one ) Rabbit_ RALGPS1 ( ortholog_one2one ) |
| Ohnologs | RALGPS2 |
| Paralogs | RALGPS2, RALGDS, RASGEF1A, RASGRF2, RASGRP3, SOS2, RAPGEF3, RAPGEF6, RASGRF1, RAPGEF2, RGL1, RAPGEF1, RASGEF1B, RASGRP2, RGL2, SOS1, RGL3, RAPGEF4, RGL4, RASGRP4, RAPGEFL1, RAPGEF5, RASGRP1, RASGEF1C |
| Tissue | NA |
| Tissue Specificity | Widely expressed (at protein level). Isoform 2 is expressed in brain, colon, kidney, pancreas, prostate, skeletal muscle, small intestine, testis, thymus and uterus. Isoform 1 is expressed at high levels in heart and testis and at lower levels in brain, pancreas, skeletal muscle, small intestine and thymus. {ECO:0000269|PubMed:10747847, ECO:0000269|PubMed:10889189}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3QXL (X-ray 2.24A ) |
| DBSNP | rs55918931 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10889189}. Cell membrane {ECO:0000269|PubMed:10889189}. Note=Associates with membranes through the PH domain. |
| Mouse PG classification | NA |
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