| Gene Information | |
|---|---|
| Gene Name | PJA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 708 |
| Protein Names | E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000198961 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O43164 |
| Gene Card | PJA2 |
| Uniprot ID | O43164 |
| Pfam | PF13639 |
| In ASD | no |
| Allosteric Prediction | no (-0.162293136) |
| Ortholog in Animals | Alpaca_ PJA2 ( ortholog_one2one ) Dog_ PJA2 ( ortholog_one2one ) GuineaPig_ PJA2 ( ortholog_one2one ) Macaque_ PJA2 ( ortholog_one2one ) Mouse_ Pja2 ( ortholog_one2one ) Pig_ PJA2 ( ortholog_one2one ) Rat_ Pja2 ( ortholog_one2one ) Rabbit_ PJA2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PJA1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35224970 rs1045706 rs246105 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21423175}. Cell membrane {ECO:0000269|PubMed:21423175}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21423175}; Peripheral membrane protein {ECO:0000269|PubMed:21423175}. Golgi apparatus membrane {ECO:0000269|PubMed:21423175}; Peripheral membrane protein {ECO:0000269|PubMed:21423175}. Synapse {ECO:0000250|UniProtKB:Q63364}. Postsynaptic density {ECO:0000250|UniProtKB:Q63364}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:33934390}. Note=Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus (PubMed:21423175). Expressed in the postsynaptic density region of synapses (By similarity). Colocalizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane (PubMed:21423175). {ECO:0000250|UniProtKB:Q63364, ECO:0000269|PubMed:21423175}. |
| Mouse PG classification | NA |
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