| Gene Information | |
|---|---|
| Gene Name | RAF |
| Organism | Homo sapiens (Human) |
| Gene Length | 648 |
| Protein Names | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P04049 |
| Gene Card | RAF1 |
| Uniprot ID | P04049 |
| Pfam | PF00130; PF07714; PF02196 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | In skeletal muscle, isoform 1 is more abundant than isoform 2. {ECO:0000269|PubMed:1886707}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1C1Y (X-ray 1.90A ) 1FAQ (NMR - ) 1FAR (NMR - ) 1GUA (X-ray 2.00A ) 1RFA (NMR - ) 3CU8 (X-ray 2.40A ) 3IQJ (X-ray 1.15A ) 3IQU (X-ray 1.05A ) 3IQV (X-ray 1.20A ) 3KUC (X-ray 1.92A ) 3KUD (X-ray 2.15A ) 3NKX (X-ray 2.40A ) 3O8I (X-ray 2.00A ) 3OMV (X-ray 4.00A ) 4FJ3 (X-ray 1.95A ) 4G0N (X-ray 2.45A ) 4G3X (X-ray 3.25A ) 4IEA (X-ray 1.70A ) 4IHL (X-ray 2.20A ) 6NTC (X-ray 2.90A ) 6NTD (X-ray 3.15A ) 6PTS (NMR - ) 6PTW (NMR - ) 6VJJ (X-ray 1.40A ) 6XGU (X-ray 2.70A ) 6XGV (X-ray 2.11A ) 6XHA (X-ray 2.87A ) 6XHB (X-ray 2.50A ) 6XI7 (X-ray 1.95A ) 7JHP (X-ray 2.77A ) |
| DBSNP | rs587777588 rs397516826 rs80338796 rs3730271 rs397516827 rs869025501 rs121434594 rs397516828 rs121434594 rs397516830 rs5746220 rs778155315 rs1057403865 rs397516815 rs80338798 rs80338799 rs80338799 rs587777586 rs1448392469 rs80338797 rs1553609795 rs587777587 |
| Subcellular location [CC] | Cytoplasm. Cell membrane. Mitochondrion. Nucleus. Note=Colocalizes with RGS14 and BRAF in both the cytoplasm and membranes. Phosphorylation at Ser-259 impairs its membrane accumulation. Recruited to the cell membrane by the active Ras protein. Phosphorylation at Ser-338 and Ser-339 by PAK1 is required for its mitochondrial localization. Retinoic acid-induced Ser-621 phosphorylated form of RAF1 is predominantly localized at the nucleus. |
| Mouse PG classification | NA |
| click here to return to the previous page | |