| Gene Information | |
|---|---|
| Gene Name | HLA-6.0 |
| Organism | Homo sapiens (Human) |
| Gene Length | 338 |
| Protein Names | HLA class I histocompatibility antigen, alpha chain G (HLA G antigen) (MHC class I antigen G) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain G (sHLA-G)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P17693 |
| Gene Card | HLA-G |
| Uniprot ID | P17693 |
| Pfam | PF07654; PF00129 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in adult eye (PubMed:1570318). Expressed in immune cell subsets including monocytes, myeloid and plasmacytoid dendritic cells and regulatory T cells (Tr1)(at protein level) (PubMed:20448110). Secreted by follicular dendritic cell and follicular helper T cells (PubMed:24453251).; [Isoform 5]: Detected in physiological fluids including amniotic fluid and serum. {ECO:0000269|PubMed:11137219}.; [Isoform 7]: Expressed in placenta, amniotic membrane, skin, cord blood and peripheral blood mononuclear cells. {ECO:0000269|PubMed:11137219}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1YDP (X-ray 1.90A ) 2D31 (X-ray 3.20A ) 2DYP (X-ray 2.50A ) 3BZE (X-ray 2.50A ) 3CDG (X-ray 3.40A ) 3CII (X-ray 4.41A ) 3KYN (X-ray 2.40A ) 3KYO (X-ray 1.70A ) 6AEE (X-ray 3.30A ) 6K60 (X-ray 3.15A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:20448110, ECO:0000269|PubMed:7584149}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11520457}. Early endosome membrane {ECO:0000269|PubMed:16366734}.; [Soluble HLA class I histocompatibility antigen, alpha chain G]: Secreted {ECO:0000269|PubMed:23737137}.; [Isoform 2]: Cell membrane {ECO:0000269|PubMed:11290782}; Single-pass type I membrane protein {ECO:0000255}.; [Isoform 3]: Cell membrane {ECO:0000269|PubMed:11290782}; Single-pass type I membrane protein {ECO:0000255}.; [Isoform 4]: Cell membrane {ECO:0000269|PubMed:11290782}; Single-pass type I membrane protein {ECO:0000255}.; [Isoform 5]: Secreted {ECO:0000269|PubMed:11137219, ECO:0000269|PubMed:7558941, ECO:0000269|PubMed:7584149, ECO:0000269|PubMed:7989753}. Early endosome {ECO:0000269|PubMed:16366734}.; [Isoform 6]: Secreted {ECO:0000269|PubMed:7989753}.; [Isoform 7]: Secreted {ECO:0000269|PubMed:11137219}.; Cell projection, filopodium membrane {ECO:0000269|PubMed:26460007}. Note=HLA-G trogocytosis from extravillous trophoblast's filopodia occurs in the majority of decidual NK cells. {ECO:0000269|PubMed:26460007}. |
| Mouse PG classification | NA |
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