| Gene Information | |
|---|---|
| Gene Name | RAD51 |
| Organism | Homo sapiens (Human) |
| Gene Length | 339 |
| Protein Names | DNA repair protein RAD51 homolog 1 (HsRAD51) (hRAD51) (RAD51 homolog A) |
| Target Name | dna repair protein rad51 homolog 1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000051180 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | Q06609 |
| Gene Card | RAD51 |
| Uniprot ID | Q06609 |
| Pfam | PF08423 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000199862) |
| Ortholog in Animals | Alpaca_ RAD51 ( ortholog_one2one ) Dog_ RAD51 ( ortholog_one2one ) GuineaPig_ RAD51 ( ortholog_one2one ) Macaque_ RAD51 ( ortholog_one2one ) Mouse_ Rad51 ( ortholog_one2one ) Pig_ RAD51 ( ortholog_one2one ) Rat_ Rad51 ( ortholog_one2one ) Rabbit_ RAD51 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RAD51D, XRCC3, RAD51C, XRCC2, RAD51B, DMC1 |
| Tissue | brain, testis |
| Tissue Specificity | Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.063320(Mouse);NULL(Rat);0.080423(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1B22 (NMR - ) 1N0W (X-ray 1.70A ) 5H1B (EM 4.40A ) 5H1C (EM 4.50A ) 5JZC (EM 4.20A ) 5NP7 (EM 4.20A ) 5NWL (X-ray 3.93A ) 7C9A (EM 3.43A ) 7EJC (EM 2.97A ) 7EJE (EM 3.98A ) |
| DBSNP | rs121917739 rs1057519413 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12442171, ECO:0000269|PubMed:15665856, ECO:0000269|PubMed:18417535, ECO:0000269|PubMed:19783859, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:26681308, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:9192668}. Cytoplasm {ECO:0000269|PubMed:16215984, ECO:0000269|PubMed:26681308}. Cytoplasm, perinuclear region. Mitochondrion matrix {ECO:0000269|PubMed:20413593}. Chromosome {ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:27797818, ECO:0000269|PubMed:31844045}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21276791}. Note=Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage (PubMed:20154705). DNA damage induces an increase in nuclear levels (PubMed:20154705). Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment (PubMed:23754376). Accumulated at sites of DNA damage in a SPIDR-dependent manner (PubMed:23509288). Recruited at sites of DNA damage in a MCM9-MCM8-dependent manner (PubMed:23401855). Colocalizes with ERCC5/XPG to nuclear foci in S phase (PubMed:26833090). Recruited to stalled replication forks during replication stress by the TONSL-MMS22L complex, as well as ATAD5 and WDR48 in an ATR-dependent manner (PubMed:27797818, PubMed:31844045). {ECO:0000269|PubMed:20154705, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:27797818, ECO:0000269|PubMed:31844045}. |
| Mouse PG classification | LPG |
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