| Gene Information | |
|---|---|
| Gene Name | PLA2G4E |
| Organism | Homo sapiens (Human) |
| Gene Length | 868 |
| Protein Names | Cytosolic phospholipase A2 epsilon (cPLA2-epsilon) (EC 3.1.1.4) (Calcium-dependent N-acyltransferase) (Phospholipase A2 group IVE) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000188089 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q3MJ16 |
| Gene Card | PLA2G4E |
| Uniprot ID | Q3MJ16 |
| Pfam | PF00168; PF18695; PF01735 |
| In ASD | no |
| Allosteric Prediction | yes (0.374266909) |
| Ortholog in Animals | Alpaca_ PLA2G4E ( ortholog_one2one ) Dog_ PLA2G4E ( ortholog_one2one ) GuineaPig_ PLA2G4E ( ortholog_one2one ) Macaque_ PLA2G4E ( ortholog_one2one ) Mouse_ Pla2g4e ( ortholog_one2one ) Pig_ PLA2G4E ( ortholog_one2one ) Rat_ Pla2g4e ( ortholog_one2one ) Rabbit_ PLA2G4E ( ortholog_one2one ) |
| Ohnologs | PLA2G4C |
| Paralogs | PLA2G4B, PLA2G4D, PLA2G4F, PLA2G4A, PLA2G4C |
| Tissue | skin, lower.leg.skin, suprapubic.skin |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs4924595 rs8030775 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q50L42}. Early endosome membrane {ECO:0000250|UniProtKB:Q50L42}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q50L42}; Cytoplasmic side {ECO:0000250|UniProtKB:Q50L42}. Lysosome membrane {ECO:0000250|UniProtKB:Q50L42}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q50L42}; Cytoplasmic side {ECO:0000250|UniProtKB:Q50L42}. Cell membrane {ECO:0000250|UniProtKB:Q50L42}; Peripheral membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:Q50L42}. Note=Targeted to clathrin-independent endocytotic vesicles through binding to phosphoinositides, especially phosphatidylinositol 4,5-bisphosphates. {ECO:0000250|UniProtKB:Q50L42}. |
| Mouse PG classification | NA |
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