| Gene Information | |
|---|---|
| Gene Name | RAD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 380 |
| Protein Names | Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P39748 |
| Gene Card | FEN1 |
| Uniprot ID | P39748 |
| Pfam | PF00867; PF00752 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003673(Rat);0.108571(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1U7B (X-ray 1.88A ) 1UL1 (X-ray 2.90A ) 3Q8K (X-ray 2.20A ) 3Q8L (X-ray 2.32A ) 3Q8M (X-ray 2.60A ) 3UVU (X-ray 2.38A ) 5E0V (X-ray 2.07A ) 5FV7 (X-ray 2.84A ) 5K97 (X-ray 2.10A ) 5KSE (X-ray 2.10A ) 5UM9 (X-ray 2.81A ) 5ZOD (X-ray 1.90A ) 5ZOE (X-ray 1.95A ) 5ZOF (X-ray 2.25A ) 5ZOG (X-ray 2.30A ) 6TNZ (EM 4.05A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.; [Isoform FENMIT]: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:23675412}. |
| Mouse PG classification | NA |
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