| Gene Information | |
|---|---|
| Gene Name | RAD18 |
| Organism | Homo sapiens (Human) |
| Gene Length | 495 |
| Protein Names | E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000070950 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9NS91 |
| Gene Card | RAD18 |
| Uniprot ID | Q9NS91 |
| Pfam | PF02037 |
| In ASD | no |
| Allosteric Prediction | no (-0.454635081) |
| Ortholog in Animals | Alpaca_ RAD18 ( ortholog_one2one ) Dog_ RAD18 ( ortholog_one2one ) GuineaPig_ RAD18 ( ortholog_one2one ) Macaque_ RAD18 ( ortholog_one2one ) Mouse_ Rad18 ( ortholog_one2one ) Pig_ RAD18 ( ortholog_one2one ) Rat_ Rad18 ( ortholog_one2one ) Rabbit_ RAD18 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.004867(Chimpanzee);0.009084(Mouse);0.002144(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2MRE (NMR - ) 2MRF (NMR - ) 2Y43 (X-ray 1.80A ) 2YBF (X-ray 2.00A ) 5VF0 (NMR - ) |
| DBSNP | rs45520133 rs373572 rs45569933 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15632077, ECO:0000269|PubMed:22036607, ECO:0000269|PubMed:25931565}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15632077}. Note=Associates with chromatin (PubMed:25931565). Colocalizes with SLF1 in the nucleus and to centrosomes (PubMed:15632077). Relocalizes with SLF1 to nuclear foci in response to DNA damage (PubMed:22036607). Accumulates with the SLF1-SLF2 and SMC5-SMC6 complexes at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). {ECO:0000269|PubMed:15632077, ECO:0000269|PubMed:22036607, ECO:0000269|PubMed:25931565}. |
| Mouse PG classification | NA |
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