Gene Information

Gene Information
Gene Name	RACK1
Organism	Homo sapiens (Human)
Gene Length	317
Protein Names	Receptor of activated protein C kinase 1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Small ribosomal subunit protein RACK1) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed)]
Target Name	receptor of activated protein c kinase 1
Target Type	NA
Gene Age	680 ( ENSG00000204628 )
Evolutionary Stage	Eukaryota
AlphaFoldDB	P63244
Gene Card	RACK1
Uniprot ID	P63244
Pfam	PF00400
In ASD	no
Allosteric Prediction	yes (1.318891697)
Ortholog in Animals	Alpaca_ RACK1 ( ortholog_one2one ) Dog_ RACK1 ( ortholog_one2one ) GuineaPig_ RACK1 ( ortholog_one2one ) Macaque_ RACK1 ( ortholog_one2one ) Mouse_ Rack1 ( ortholog_one2one ) Pig_ RACK1 ( ortholog_one2one ) Rat_ Rack1 ( ortholog_one2one )
Ohnologs	NA
Paralogs	NA
Tissue	NA
Tissue Specificity	In the liver, expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue. {ECO:0000269\|PubMed:18621736}.
Pharmacological Animal Models	NA
Gene Ontology (biological process)
Gene Ontology (cellular component)
Gene Ontology (molecular function)
PDB	4AOW (X-ray 2.45A ) 4UG0 (EM - ) 4V6X (EM 5.00A ) 5A2Q (EM 3.90A ) 5AJ0 (EM 3.50A ) 5FLX (EM 3.90A ) 5LKS (EM 3.60A ) 5OA3 (EM 4.30A ) 5T2C (EM 3.60A ) 5VYC (X-ray 6.00A ) 6FEC (EM 6.30A ) 6G18 (EM 3.60A ) 6G51 (EM 4.10A ) 6G53 (EM 4.50A ) 6G5H (EM 3.60A ) 6G5I (EM 3.50A ) 6IP5 (EM 3.90A ) 6IP6 (EM 4.50A ) 6IP8 (EM 3.90A ) 6OLE (EM 3.10A ) 6OLF (EM 3.90A ) 6OLG (EM 3.40A ) 6OLI (EM 3.50A ) 6OLZ (EM 3.90A ) 6OM0 (EM 3.10A ) 6OM7 (EM 3.70A ) 6QZP (EM 2.90A ) 6XA1 (EM 2.80A ) 6Y0G (EM 3.20A ) 6Y2L (EM 3.00A ) 6Y57 (EM 3.50A ) 6YBS (EM 3.10A ) 6Z6L (EM 3.00A ) 6Z6M (EM 3.10A ) 6Z6N (EM 2.90A ) 6ZLW (EM 2.60A ) 6ZM7 (EM 2.70A ) 6ZME (EM 3.00A ) 6ZMI (EM 2.60A ) 6ZMO (EM 3.10A ) 6ZMT (EM 3.00A ) 6ZMW (EM 3.70A ) 6ZN5 (EM 3.20A ) 6ZOJ (EM 2.80A ) 6ZOL (EM 2.80A ) 6ZON (EM 3.00A ) 6ZP4 (EM 2.90A ) 6ZUO (EM 3.10A ) 6ZV6 (EM 2.90A ) 6ZVH (EM 2.90A ) 6ZVJ (EM 3.80A ) 6ZXD (EM 3.20A ) 6ZXE (EM 3.00A ) 6ZXF (EM 3.70A ) 6ZXG (EM 2.60A ) 6ZXH (EM 2.70A ) 7A09 (EM 3.50A ) 7K5I (EM 2.90A ) 7QP6 (EM 4.70A ) 7QP7 (EM 3.70A ) 7TQL (EM 3.40A )
DBSNP	NA
Subcellular location [CC]	Cell membrane {ECO:0000269\|PubMed:11312657, ECO:0000269\|PubMed:17956333}; Peripheral membrane protein. Cytoplasm {ECO:0000269\|PubMed:10849009, ECO:0000269\|PubMed:11279199, ECO:0000269\|PubMed:12958311, ECO:0000269\|PubMed:19785988, ECO:0000269\|PubMed:20499158, ECO:0000269\|PubMed:20573744, ECO:0000269\|PubMed:29743600}. Cytoplasm, perinuclear region {ECO:0000269\|PubMed:11279199, ECO:0000269\|PubMed:12958311}. Nucleus {ECO:0000269\|PubMed:10849009}. Perikaryon {ECO:0000250\|UniProtKB:P68040}. Cell projection, dendrite {ECO:0000250\|UniProtKB:P68040}. Cell projection, phagocytic cup {ECO:0000269\|PubMed:21347310}. Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1 (PubMed:17956333). Also associated with the membrane in oncogene-transformed cells (PubMed:11884618). PKC activation induces translocation from the perinuclear region to the cell periphery (PubMed:11279199). In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity). Localized to phagocytic cups following infection by Y.pestis (PubMed:21347310). {ECO:0000250\|UniProtKB:P68040, ECO:0000269\|PubMed:11279199, ECO:0000269\|PubMed:11884618, ECO:0000269\|PubMed:17956333, ECO:0000269\|PubMed:21347310}.
Mouse PG classification	NA
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