| Gene Information | |
|---|---|
| Gene Name | RAC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 192 |
| Protein Names | Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2) |
| Target Name | nadph oxidase |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000128340 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P15153 |
| Gene Card | RAC2 |
| Uniprot ID | P15153 |
| Pfam | PF00071 |
| In ASD | no |
| Allosteric Prediction | no (-0.111455884) |
| Ortholog in Animals | Alpaca_ RAC2 ( ortholog_one2one ) Dog_ RAC2 ( ortholog_one2one ) GuineaPig_ RAC2 ( ortholog_one2one ) Macaque_ RAC2 ( ortholog_one2one ) Mouse_ Rac2 ( ortholog_one2one ) Pig_ RAC2 ( ortholog_one2one ) Rat_ Rac2 ( ortholog_one2one ) Rabbit_ RAC2 ( ortholog_one2one ) |
| Ohnologs | RAC1, RAC3 |
| Paralogs | RND1, CDC42, RHOT1, RHOBTB3, RHOT2, RAC1, RAC3, RHOJ, RHOA, RHOC, RHOB, RHOV, RHOQ, RHOBTB2, RND2, RND3, RHOD, RHOF, RHOG, RHOU, RHOBTB1, RHOH |
| Tissue | NA |
| Tissue Specificity | Hematopoietic specific. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1DS6 (X-ray 2.35A ) 2W2T (X-ray 1.95A ) 2W2V (X-ray 2.00A ) 2W2X (X-ray 2.30A ) |
| DBSNP | rs74315507 rs1555908409 |
| Subcellular location [CC] | Cytoplasm. Note=Membrane-associated when activated. |
| Mouse PG classification | NA |
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