| Gene Information | |
|---|---|
| Gene Name | RAC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 192 |
| Protein Names | Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1) |
| Target Name | nadph oxidase |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000136238 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P63000 |
| Gene Card | RAC1 |
| Uniprot ID | P63000 |
| Pfam | PF00071 |
| In ASD | no |
| Allosteric Prediction | yes (0.883504023) |
| Ortholog in Animals | Alpaca_ RAC1 ( ortholog_one2one ) Dog_ RAC1 ( ortholog_one2many ) GuineaPig_ RAC1 ( ortholog_one2one ) Macaque_ RAC1 ( ortholog_one2one ) Mouse_ Rac1 ( ortholog_one2one ) Pig_ RAC1 ( ortholog_one2one ) Rat_ Rac1 ( ortholog_one2one ) Rabbit_ RAC1 ( ortholog_one2one ) |
| Ohnologs | RAC2, RAC3 |
| Paralogs | RAC3, RND1, CDC42, RHOT1, RHOBTB3, RHOT2, RHOJ, RHOA, RHOC, RHOB, RHOV, RHOQ, RHOBTB2, RND2, RND3, RHOD, RHOF, RHOG, RHOU, RAC2, RHOBTB1, RHOH |
| Tissue | NA |
| Tissue Specificity | Isoform B is predominantly identified in skin and epithelial tissues from the intestinal tract. Its expression is elevated in colorectal tumors at various stages of neoplastic progression, as compared to their respective adjacent tissues. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.026374(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1E96 (X-ray 2.40A ) 1FOE (X-ray 2.80A ) 1G4U (X-ray 2.30A ) 1HE1 (X-ray 2.00A ) 1HH4 (X-ray 2.70A ) 1I4D (X-ray 2.50A ) 1I4L (X-ray 2.70A ) 1I4T (X-ray 2.60A ) 1MH1 (X-ray 1.38A ) 1RYF (X-ray 1.75A ) 1RYH (X-ray 1.75A ) 2FJU (X-ray 2.20A ) 2H7V (X-ray 2.60A ) 2NZ8 (X-ray 2.00A ) 2P2L (X-ray 1.90A ) 2RMK (NMR - ) 2VRW (X-ray 1.85A ) 2WKP (X-ray 1.90A ) 2WKQ (X-ray 1.60A ) 2WKR (X-ray 2.20A ) 2YIN (X-ray 2.70A ) 3B13 (X-ray 3.01A ) 3BJI (X-ray 2.60A ) 3RYT (X-ray 3.58A ) 3SBD (X-ray 2.10A ) 3SBE (X-ray 2.60A ) 3SU8 (X-ray 3.20A ) 3SUA (X-ray 4.39A ) 3TH5 (X-ray 2.30A ) 4GZL (X-ray 2.00A ) 4GZM (X-ray 2.80A ) 4YON (X-ray 1.95A ) 5FI0 (X-ray 3.28A ) 5HZH (X-ray 2.60A ) 5N6O (X-ray 2.59A ) 5O33 (X-ray 1.64A ) 5QQD (X-ray 1.91A ) 5QQE (X-ray 1.95A ) 5QQF (X-ray 2.26A ) 5QQG (X-ray 2.23A ) 5QQH (X-ray 2.09A ) 5QQI (X-ray 2.08A ) 5QQJ (X-ray 1.90A ) 5QQK (X-ray 2.24A ) 5QQL (X-ray 2.25A ) 5QQM (X-ray 2.02A ) 5QQN (X-ray 2.26A ) 5QU9 (X-ray 2.00A ) 6AGP (NMR - ) 6BC1 (X-ray 2.90A ) 6TGC (EM 4.10A ) 6X1G (X-ray 1.60A ) 7AJK (X-ray 3.10A ) 7DPA (EM 3.80A ) 7SJ4 (EM 2.86A ) |
| DBSNP | rs1554263326 rs5830 rs5832 rs1554263624 rs1554263625 rs1554263625 rs5837 rs5831 rs1554263626 rs5826 rs5825 rs5838 rs5828 rs5835 rs11540455 rs1554264268 rs16063 rs5836 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:1643658, ECO:0000269|PubMed:29074776}; Lipid-anchor {ECO:0000269|PubMed:1903399}; Cytoplasmic side {ECO:0000269|PubMed:1643658, ECO:0000269|PubMed:19948726}. Melanosome {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:19948726, ECO:0000269|PubMed:21693584}. Cytoplasm {ECO:0000269|PubMed:19948726, ECO:0000269|PubMed:29074776}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P63001}. Cell projection, dendrite {ECO:0000250|UniProtKB:P63001}. Synapse {ECO:0000250|UniProtKB:Q6RUV5}. Nucleus {ECO:0000269|PubMed:12551911}. Note=Inner surface of plasma membrane possibly with attachment requiring prenylation of the C-terminal cysteine (PubMed:1903399). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Localizes to the lamellipodium in a SH3RF1-dependent manner (By similarity). In macrophages, cytoplasmic location increases upon CSF1 stimulation (By similarity). Activation by GTP-binding promotes nuclear localization (PubMed:12551911). {ECO:0000250|UniProtKB:P63001, ECO:0000250|UniProtKB:Q6RUV5, ECO:0000269|PubMed:12551911, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:1903399}. |
| Mouse PG classification | NA |
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