| Gene Information | |
|---|---|
| Gene Name | RAC |
| Organism | Homo sapiens (Human) |
| Gene Length | 480 |
| Protein Names | RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P31749 |
| Gene Card | AKT1 |
| Uniprot ID | P31749 |
| Pfam | PF00169; PF00069; PF00433 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Expressed in all human cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages. {ECO:0000269|PubMed:1718748, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:20333297}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1H10 (X-ray 1.40A ) 1UNP (X-ray 1.65A ) 1UNQ (X-ray 0.98A ) 1UNR (X-ray 1.25A ) 2UVM (X-ray 1.94A ) 2UZR (X-ray 1.94A ) 2UZS (X-ray 2.46A ) 3CQU (X-ray 2.20A ) 3CQW (X-ray 2.00A ) 3MV5 (X-ray 2.47A ) 3MVH (X-ray 2.01A ) 3O96 (X-ray 2.70A ) 3OCB (X-ray 2.70A ) 3OW4 (X-ray 2.60A ) 3QKK (X-ray 2.30A ) 3QKL (X-ray 1.90A ) 3QKM (X-ray 2.20A ) 4EJN (X-ray 2.19A ) 4EKK (X-ray 2.80A ) 4EKL (X-ray 2.00A ) 4GV1 (X-ray 1.49A ) 5KCV (X-ray 2.70A ) 6BUU (X-ray 2.40A ) 6CCY (X-ray 2.18A ) 6HHF (X-ray 2.90A ) 6HHG (X-ray 2.30A ) 6HHH (X-ray 2.70A ) 6HHI (X-ray 2.70A ) 6HHJ (X-ray 2.30A ) 6NPZ (X-ray 2.12A ) 6S9W (X-ray 2.30A ) 6S9X (X-ray 2.60A ) 7APJ (X-ray 2.05A ) 7NH4 (X-ray 2.30A ) 7NH5 (X-ray 1.90A ) |
| DBSNP | rs121434592 rs397514644 rs11555433 rs397514645 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:P31750}. Nucleus {ECO:0000269|PubMed:20333297}. Cell membrane {ECO:0000269|PubMed:20333297}. Note=Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus. Colocalizes with WDFY2 in intracellular vesicles (PubMed:16792529). {ECO:0000269|PubMed:16792529}. |
| Mouse PG classification | NA |
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