| Gene Information | |
|---|---|
| Gene Name | LOXL3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 753 |
| Protein Names | Lysyl oxidase homolog 3 (EC 1.4.3.-) (EC 1.4.3.13) (Lysyl oxidase-like protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000115318 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P58215 |
| Gene Card | LOXL3 |
| Uniprot ID | P58215 |
| Pfam | PF01186; PF00530 |
| In ASD | no |
| Allosteric Prediction | no (-1.000003645) |
| Ortholog in Animals | Alpaca_ LOXL3 ( ortholog_one2one ) Dog_ LOXL3 ( ortholog_one2one ) GuineaPig_ LOXL3 ( ortholog_one2one ) Macaque_ LOXL3 ( ortholog_one2one ) Mouse_ Loxl3 ( ortholog_one2one ) Pig_ LOXL3 ( ortholog_one2one ) Rat_ Loxl3 ( ortholog_one2one ) Rabbit_ LOXL3 ( ortholog_one2one ) |
| Ohnologs | LOXL2, LOXL4 |
| Paralogs | CD6, LOX, SSC4D, SSC5D, LGALS3BP, LOXL4, SCART1, CD163, PRSS12, DMBT1, CD5, LOXL1, CD5L, LOXL2, CD163L1 |
| Tissue | NA |
| Tissue Specificity | Isoform 1: Predominantly detected in the heart, placenta, lung, and small intestine (PubMed:17018530). Isoform 2: Highly detected in the kidney, pancreas, spleen, and thymus, and is absent in lung (PubMed:17018530). In eye, present in all layers of corneas as well as in the limbus and conjunctiva (at protein level) (PubMed:26218558). {ECO:0000269|PubMed:17018530, ECO:0000269|PubMed:26218558}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs17010021 rs786204838 |
| Subcellular location [CC] | Secreted, extracellular space {ECO:0000250|UniProtKB:Q9Z175}. Cytoplasm {ECO:0000269|PubMed:28065600}. Nucleus {ECO:0000269|PubMed:28065600}. Note=It is unclear how LOXL3 is both intracellular (cytoplasmic and nuclear) and extracellular: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, the intracellular location is clearly reported and at least another protein of the family (LOXL2) also has intracellular and extracellular localization despite the presence of a signal sequence (PubMed:28065600). {ECO:0000269|PubMed:28065600}.; [Isoform 1]: Secreted, extracellular space {ECO:0000305}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:17018530}. Secreted, extracellular space {ECO:0000269|PubMed:17018530}. |
| Mouse PG classification | NA |
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