Gene Information
Gene NameRAB7
OrganismHomo sapiens (Human)
Gene Length207
Protein NamesRas-related protein Rab-7a (EC 3.6.5.2)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP51149
Gene CardRAB7A
Uniprot IDP51149
PfamPF00071
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityWidely expressed;
high expression found in skeletal muscle. {ECO:0000269|PubMed:12545426}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.152814(Rat);0.097414(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1T91  (X-ray  1.90A  )  1YHN  (X-ray  3.00A  )  3LAW  (X-ray  2.80A  )  6IYB  (X-ray  2.09A  )  6WCW  (X-ray  2.80A  )  7F6J  (X-ray  2.10A  ) 
DBSNP rs11549759  rs121909078  rs121909081  rs121909080  rs121909079 
Subcellular location [CC]Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:21255211};
Peripheral membrane protein {ECO:0000305};
Cytoplasmic side {ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:20028791, ECO:0000269|PubMed:28325809};
Peripheral membrane protein {ECO:0000305};
Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:20028791};
Peripheral membrane protein {ECO:0000305};
Cytoplasmic side {ECO:0000305}. Melanosome membrane {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065};
Peripheral membrane protein {ECO:0000305};
Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:20028791};
Peripheral membrane protein {ECO:0000305};
Cytoplasmic side {ECO:0000305}. Lipid droplet {ECO:0000250|UniProtKB:P51150}. Endosome membrane {ECO:0000269|PubMed:22431521};
Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P51150}. Mitochondrion membrane {ECO:0000305|PubMed:34432599};
Peripheral membrane protein {ECO:0000305}. Note=Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Recruited to phagosomes containing S.aureus or Mycobacterium (PubMed:21255211). Lipid droplet localization is increased upon ADRB2 stimulation (By similarity). Recruited to damaged mitochondria during mitophagy in a RIMOC1-dependent manner (PubMed:34432599). {ECO:0000250|UniProtKB:P51150, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:34432599}.
Mouse PG classificationNA
click here to return to the previous page