| Gene Information | |
|---|---|
| Gene Name | RAB4A |
| Organism | Homo sapiens (Human) |
| Gene Length | 218 |
| Protein Names | Ras-related protein Rab-4A (EC 3.6.5.2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000168118 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P20338 |
| Gene Card | RAB4A |
| Uniprot ID | P20338 |
| Pfam | PF00071 |
| In ASD | no |
| Allosteric Prediction | yes (0.098603582) |
| Ortholog in Animals | Alpaca_ RAB4A ( ortholog_one2one ) Dog_ RAB4A ( ortholog_one2one ) GuineaPig_ RAB4A ( ortholog_one2one ) Macaque_ RAB4A ( ortholog_one2one ) Mouse_ Rab4a ( ortholog_one2one ) Pig_ RAB4A ( ortholog_one2one ) Rat_ Rab4a ( ortholog_one2one ) Rabbit_ RAB4A ( ortholog_one2one ) |
| Ohnologs | RAB4B |
| Paralogs | RAB14, RAB5C, RAB39A, RAB27B, RAB36, RAB33B, RABL2A, RABL2B, RAB27A, RAB3C, RAB5A, RAB15, RAB40AL, RAB3A, RAB40C, RAB12, RAB8A, RAB17, RAB20, RAB24, RAB44, RAB1A, RAB11A, RAB31, RAB7A, IFT27, RAB29, RAB33A, RAB9B, RAB10, RAB4B, RAB32, RAB19, RAB42, RAB9A, RAB40A, RAB11B, RAB2B, RAB2A, RAB43, RAB18, RAB37, RAB25, RASEF, RAB6D, RAB6C, RAB8B, RAB41, RAB40B, RAB21, RAB39B, RAB28, RAB5B, RAB13, RAB38, RAB3B, RAB34, RAB7B, RAB35, RAB3D, RAB1B, RAB6B, RAB22A, RAB26, RAB23, RAB30, RAB6A, DNAJC27 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.044444(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1YU9 (X-ray 2.07A ) 1Z0K (X-ray 1.92A ) 2BMD (X-ray 1.80A ) 2BME (X-ray 1.57A ) |
| DBSNP | NA |
| Subcellular location [CC] | Membrane; Peripheral membrane protein {ECO:0000269|PubMed:1425574}. Cytoplasm {ECO:0000269|PubMed:1425574}. Early endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Recycling endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1. {ECO:0000269|PubMed:1425574}. |
| Mouse PG classification | NA |
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