| Gene Information | |
|---|---|
| Gene Name | ARHGEF40 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1519 |
| Protein Names | Rho guanine nucleotide exchange factor 40 (Protein SOLO) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000165801 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q8TER5 |
| Gene Card | ARHGEF40 |
| Uniprot ID | Q8TER5 |
| Pfam | PF00621 |
| In ASD | no |
| Allosteric Prediction | no (-1.100878298) |
| Ortholog in Animals | Alpaca_ ARHGEF40 ( ortholog_one2one ) Dog_ ARHGEF40 ( ortholog_one2one ) GuineaPig_ ARHGEF40 ( ortholog_one2one ) Macaque_ ARHGEF40 ( ortholog_one2one ) Mouse_ Arhgef40 ( ortholog_one2one ) Pig_ ARHGEF40 ( ortholog_one2one ) Rat_ Arhgef40 ( ortholog_one2one ) Rabbit_ ARHGEF40 ( ortholog_one2one ) |
| Ohnologs | PLEKHG4, PLEKHG4B |
| Paralogs | MCF2L2, VAV1, PLEKHN1, PLEKHG4, TIAM2, ARHGEF25, VAV2, VAV3, SPATA13, ARHGEF9, ARHGEF6, PLEKHG1, SESTD1, PLEKHG2, KIAA1755, PLEKHG4B, TIAM1, MCF2, KALRN, ARHGEF7, MCF2L, TRIO |
| Tissue | NA |
| Tissue Specificity | Expressed at higher level in the central nervous system and skeletal muscle and greater abundance in fetal than adult brain (at protein level). {ECO:0000269|PubMed:16143467}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7143633 rs1958396 rs943992 rs17855344 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16143467}. Note=Concentrated in the perinuclear region. |
| Mouse PG classification | NA |
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