| Gene Information | |
|---|---|
| Gene Name | RAB2B |
| Organism | Homo sapiens (Human) |
| Gene Length | 216 |
| Protein Names | Ras-related protein Rab-2B (EC 3.6.5.2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000129472 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8WUD1 |
| Gene Card | RAB2B |
| Uniprot ID | Q8WUD1 |
| Pfam | PF00071 |
| In ASD | no |
| Allosteric Prediction | no (-1.310960761) |
| Ortholog in Animals | Alpaca_ RAB2B ( ortholog_one2one ) Dog_ RAB2B ( ortholog_one2many ) GuineaPig_ RAB2B ( ortholog_one2one ) Macaque_ RAB2B ( ortholog_one2one ) Mouse_ Rab2b ( ortholog_one2one ) Pig_ RAB2B ( ortholog_one2one ) Rat_ Rab2b ( ortholog_one2one ) Rabbit_ RAB2B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RAB2A, RAB14, RAB5C, RAB39A, RAB27B, RAB36, RAB33B, RABL2A, RABL2B, RAB27A, RAB3C, RAB5A, RAB15, RAB40AL, RAB3A, RAB40C, RAB12, RAB8A, RAB17, RAB20, RAB24, RAB44, RAB1A, RAB11A, RAB31, RAB7A, IFT27, RAB29, RAB33A, RAB9B, RAB10, RAB4B, RAB32, RAB4A, RAB19, RAB42, RAB9A, RAB40A, RAB11B, RAB43, RAB18, RAB37, RAB25, RASEF, RAB6D, RAB6C, RAB8B, RAB41, RAB40B, RAB21, RAB39B, RAB28, RAB5B, RAB13, RAB38, RAB3B, RAB34, RAB7B, RAB35, RAB3D, RAB1B, RAB6B, RAB22A, RAB26, RAB23, RAB30, RAB6A, DNAJC27 |
| Tissue | NA |
| Tissue Specificity | Expressed in kidney, prostate, lung, liver, thymus, colon, pancreas, and skeletal muscle, and low levels in placenta. Not detected in heart, brain, spleen, testis, ovary, small intestine and leukocyte. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2A5J (X-ray 1.50A ) |
| DBSNP | rs17106411 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:P59279}; Lipid-anchor {ECO:0000250|UniProtKB:P59279}; Cytoplasmic side {ECO:0000250|UniProtKB:P59279}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P59279}; Lipid-anchor {ECO:0000250|UniProtKB:P59279}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P59279}; Lipid-anchor {ECO:0000250|UniProtKB:P59279}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:P59279}. Note=Localized in the Golgi apparatus in the round spermatids and in the acrosome in the elongating spermatid. {ECO:0000250|UniProtKB:P59279}. |
| Mouse PG classification | NA |
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