| Gene Information | |
|---|---|
| Gene Name | RAB25 |
| Organism | Homo sapiens (Human) |
| Gene Length | 213 |
| Protein Names | Ras-related protein Rab-25 (CATX-8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000132698 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P57735 |
| Gene Card | RAB25 |
| Uniprot ID | P57735 |
| Pfam | PF00071 |
| In ASD | no |
| Allosteric Prediction | no (-0.849581197) |
| Ortholog in Animals | Alpaca_ RAB25 ( ortholog_one2one ) Dog_ RAB25 ( ortholog_one2one ) GuineaPig_ RAB25 ( ortholog_one2one ) Macaque_ RAB25 ( ortholog_one2one ) Mouse_ Rab25 ( ortholog_one2one ) Pig_ RAB25 ( ortholog_one2one ) Rat_ Rab25 ( ortholog_one2one ) Rabbit_ RAB25 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RAB14, RAB5C, RAB39A, RAB27B, RAB36, RAB33B, RABL2A, RABL2B, RAB27A, RAB3C, RAB5A, RAB15, RAB40AL, RAB3A, RAB40C, RAB12, RAB8A, RAB17, RAB20, RAB24, RAB44, RAB1A, RAB11A, RAB31, RAB7A, IFT27, RAB29, RAB33A, RAB9B, RAB10, RAB4B, RAB32, RAB4A, RAB19, RAB42, RAB9A, RAB40A, RAB11B, RAB2B, RAB2A, RAB43, RAB18, RAB37, RASEF, RAB6D, RAB6C, RAB8B, RAB41, RAB40B, RAB21, RAB39B, RAB28, RAB5B, RAB13, RAB38, RAB3B, RAB34, RAB7B, RAB35, RAB3D, RAB1B, RAB6B, RAB22A, RAB26, RAB23, RAB30, RAB6A, DNAJC27 |
| Tissue | NA |
| Tissue Specificity | Expressed in ovarian epithelium (NOE) and breast tissue. Expressed in ovarian cancer; expression is increased relative to NOE cells. Expression in ovarian cancer is stage dependent, with stage III and stage IV showing higher levels than early stage cancers. Expressed in breast cancer; expression is increased relative to normal breast tissue. {ECO:0000269|PubMed:15502842}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2OIL (X-ray 2.30A ) 3TSO (X-ray 1.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, pseudopodium membrane {ECO:0000269|PubMed:17925226}. Cytoplasmic vesicle {ECO:0000269|PubMed:17925226}. Note=Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips. {ECO:0000269|PubMed:17925226}. |
| Mouse PG classification | NA |
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