| Gene Information | |
|---|---|
| Gene Name | QSOX1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 747 |
| Protein Names | Sulfhydryl oxidase 1 (hQSOX) (EC 1.8.3.2) (Quiescin Q6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000116260 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O00391 |
| Gene Card | QSOX1 |
| Uniprot ID | O00391 |
| Pfam | PF04777; PF18371; PF18108; PF00085 |
| In ASD | no |
| Allosteric Prediction | yes (0.138269855) |
| Ortholog in Animals | Alpaca_ QSOX1 ( ortholog_one2one ) Dog_ QSOX1 ( ortholog_one2one ) GuineaPig_ QSOX1 ( ortholog_one2one ) Macaque_ QSOX1 ( ortholog_one2one ) Mouse_ Qsox1 ( ortholog_one2one ) Pig_ QSOX1 ( ortholog_one2one ) Rat_ Qsox1 ( ortholog_one2one ) Rabbit_ QSOX1 ( ortholog_one2one ) |
| Ohnologs | QSOX2 |
| Paralogs | QSOX2 |
| Tissue | NA |
| Tissue Specificity | Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney. {ECO:0000269|PubMed:10708601, ECO:0000269|Ref.8}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3LLI (X-ray 2.05A ) 3LLK (X-ray 2.00A ) 3Q6O (X-ray 2.05A ) 4IJ3 (X-ray 2.70A ) |
| DBSNP | rs3894211 rs17855475 rs4360492 rs2278943 rs12371 rs3738115 rs16855466 |
| Subcellular location [CC] | [Isoform 1]: Golgi apparatus membrane {ECO:0000269|PubMed:17331072, ECO:0000269|PubMed:23704371}; Single-pass membrane protein {ECO:0000305|PubMed:17331072}. Secreted {ECO:0000269|PubMed:29757379}. Note=A small proportion is secreted, probably via a proteolytic cleavage that removes the membrane anchor. {ECO:0000305|PubMed:29757379}.; [Isoform 2]: Secreted {ECO:0000269|PubMed:10708601}. Note=Found in the extracellular medium of quiescent cells but is not found in proliferating cells. {ECO:0000269|PubMed:10708601}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |