| Gene Information | |
|---|---|
| Gene Name | QPCT |
| Organism | Homo sapiens (Human) |
| Gene Length | 361 |
| Protein Names | Glutaminyl-peptide cyclotransferase (EC 2.3.2.5) (Glutaminyl cyclase) (QC) (sQC) (Glutaminyl-tRNA cyclotransferase) (Glutamyl cyclase) (EC) |
| Target Name | glutaminyl cyclase |
| Target Type | Clinical trial target |
| Gene Age | 1488 ( ENSG00000115828 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q16769 |
| Gene Card | QPCT |
| Uniprot ID | Q16769 |
| Pfam | PF04389 |
| In ASD | no |
| Allosteric Prediction | yes (0.443235546) |
| Ortholog in Animals | Alpaca_ QPCT ( ortholog_one2one ) Dog_ QPCT ( ortholog_one2one ) GuineaPig_ QPCT ( ortholog_one2one ) Macaque_ QPCT ( ortholog_one2one ) Mouse_ Qpct ( ortholog_one2one ) Pig_ QPCT ( ortholog_one2one ) Rat_ Qpct ( ortholog_one2one ) Rabbit_ QPCT ( ortholog_one2one ) |
| Ohnologs | QPCTL |
| Paralogs | QPCTL |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2AFM (X-ray 1.66A ) 2AFO (X-ray 2.35A ) 2AFS (X-ray 2.22A ) 2AFU (X-ray 2.22A ) 2AFW (X-ray 1.56A ) 2AFX (X-ray 1.64A ) 2AFZ (X-ray 1.68A ) 2ZED (X-ray 1.70A ) 2ZEE (X-ray 1.99A ) 2ZEF (X-ray 1.67A ) 2ZEG (X-ray 2.08A ) 2ZEH (X-ray 1.80A ) 2ZEL (X-ray 1.97A ) 2ZEM (X-ray 2.18A ) 2ZEN (X-ray 1.78A ) 2ZEO (X-ray 1.66A ) 2ZEP (X-ray 2.10A ) 3PBB (X-ray 1.95A ) 3PBE (X-ray 1.95A ) 3SI0 (X-ray 2.10A ) 4YU9 (X-ray 2.10A ) 4YWY (X-ray 1.95A ) 6GBX (X-ray 1.72A ) 6YI1 (X-ray 1.92A ) 6YJY (X-ray 1.67A ) 7CM0 (X-ray 2.20A ) 7COZ (X-ray 1.85A ) 7CP0 (X-ray 1.70A ) 7D8E (X-ray 2.00A ) |
| DBSNP | rs2255991 rs895245310 rs4670696 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:18486145}. |
| Mouse PG classification | NA |
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