| Gene Information | |
|---|---|
| Gene Name | QARS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 775 |
| Protein Names | Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000172053 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P47897 |
| Gene Card | QARS1 |
| Uniprot ID | P47897 |
| Pfam | PF00749; PF03950; PF04558; PF04557 |
| In ASD | no |
| Allosteric Prediction | yes (0.429762373) |
| Ortholog in Animals | Alpaca_ QARS1 ( ortholog_one2one ) Dog_ QARS1 ( ortholog_one2one ) GuineaPig_ QARS1 ( ortholog_one2one ) Macaque_ QARS1 ( ortholog_one2one ) Mouse_ Qars ( ortholog_one2one ) Pig_ QARS1 ( ortholog_one2one ) Rat_ Qars1 ( ortholog_one2one ) Rabbit_ QARS1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EARS2, EPRS1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in fetal cerebral cortex, particularly in the ventricular zone, inner subventricular zone, outer subventricular zone, and cortical plate. {ECO:0000269|PubMed:24656866}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.038751(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4R3Z (X-ray 4.03A ) 4YE6 (X-ray 2.40A ) 4YE8 (X-ray 3.30A ) 4YE9 (X-ray 2.70A ) |
| DBSNP | rs587777331 rs587777333 rs587777332 rs587777334 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:19289464}. Cytoplasm {ECO:0000269|PubMed:10791971, ECO:0000269|PubMed:24656866}. |
| Mouse PG classification | NA |
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