Gene Information
Gene NameALKBH2
OrganismHomo sapiens (Human)
Gene Length261
Protein NamesDNA oxidative demethylase ALKBH2 (EC 1.14.11.33) (Alkylated DNA repair protein alkB homolog 2) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2) (Oxy DC1)
Target Namealpha-ketoglutarate-dependent dioxygenase alkb homolog 2
Target TypeNA
Gene Age544 ( ENSG00000189046 )
Evolutionary StageEukaryota
AlphaFoldDBQ6NS38
Gene CardALKBH2
Uniprot IDQ6NS38
PfamPF13532
In ASDno
Allosteric Predictionno (-0.992886935)
Ortholog in AnimalsAlpaca_ ALKBH2 ( ortholog_one2many )
Dog_ ALKBH2 ( ortholog_one2one )
GuineaPig_ ALKBH2 ( ortholog_one2one )
Macaque_ ALKBH2 ( ortholog_one2one )
Mouse_ Alkbh2 ( ortholog_one2one )
Pig_ ALKBH2 ( ortholog_one2one )
Rat_ Alkbh2 ( ortholog_one2one )
Rabbit_ ALKBH2 ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityDetected in colon, small intestine, ovary, testis, prostate, skeletal muscle, heart, liver and urinary bladder. {ECO:0000269|PubMed:12486230, ECO:0000269|PubMed:16174769}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3BTX  (X-ray  2.00A  )  3BTY  (X-ray  2.35A  )  3BTZ  (X-ray  3.00A  )  3BU0  (X-ray  2.50A  )  3BUC  (X-ray  2.59A  )  3H8O  (X-ray  2.50A  )  3H8R  (X-ray  1.77A  )  3H8X  (X-ray  2.50A  )  3RZG  (X-ray  1.62A  )  3RZH  (X-ray  2.25A  )  3RZJ  (X-ray  2.50A  )  3RZK  (X-ray  2.78A  )  3RZL  (X-ray  2.60A  )  3RZM  (X-ray  3.06A  )  3S57  (X-ray  1.60A  )  3S5A  (X-ray  1.70A  )  4MG2  (X-ray  2.30A  )  4MGT  (X-ray  2.60A  ) 
DBSNP rs138073204  rs33962311 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:12486230, ECO:0000269|PubMed:12594517, ECO:0000269|PubMed:19736315}. Nucleus, nucleolus {ECO:0000269|PubMed:23972994}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23972994}. Note=Relocates to the replication foci during S-phase. {ECO:0000269|PubMed:12594517}.
Mouse PG classificationNA
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