| Gene Information | |
|---|---|
| Gene Name | PYPAF7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1061 |
| Protein Names | NACHT, LRR and PYD domains-containing protein 12 (Monarch-1) (PYRIN-containing APAF1-like protein 7) (Regulated by nitric oxide) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P59046 |
| Gene Card | NLRP12 |
| Uniprot ID | P59046 |
| Pfam | PF14484; PF13516; PF05729; PF17776; PF17779; PF02758 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes. {ECO:0000269|PubMed:11167794}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2L6A (NMR - ) 4XHS (X-ray 1.70A ) 5H7N (X-ray 1.85A ) |
| DBSNP | rs34436714 rs34971363 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:30902577}. |
| Mouse PG classification | NA |
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