| Gene Information | |
|---|---|
| Gene Name | VCL |
| Organism | Homo sapiens (Human) |
| Gene Length | 1134 |
| Protein Names | Vinculin (Metavinculin) (MV) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000035403 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P18206 |
| Gene Card | VCL |
| Uniprot ID | P18206 |
| Pfam | PF01044 |
| In ASD | no |
| Allosteric Prediction | yes (0.458709197) |
| Ortholog in Animals | Alpaca_ VCL ( ortholog_one2one ) Dog_ VCL ( ortholog_one2one ) GuineaPig_ VCL ( ortholog_one2one ) Macaque_ VCL ( ortholog_one2one ) Mouse_ Vcl ( ortholog_one2one ) Pig_ VCL ( ortholog_one2one ) Rat_ Vcl ( ortholog_one2one ) Rabbit_ VCL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CTNNA2, CTNNA3, CTNNA1, CTNNAL1 |
| Tissue | NA |
| Tissue Specificity | Metavinculin is muscle-specific. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1RKC (X-ray 2.70A ) 1RKE (X-ray 2.35A ) 1SYQ (X-ray 2.42A ) 1TR2 (X-ray 2.90A ) 1YDI (X-ray 1.80A ) 2GWW (X-ray 2.72A ) 2HSQ (X-ray 3.97A ) 2IBF (X-ray 3.20A ) 3H2U (X-ray 2.75A ) 3H2V (X-ray 2.90A ) 3JBK (EM 8.20A ) 3MYI (X-ray 2.20A ) 3RF3 (X-ray 1.61A ) 3S90 (X-ray 1.97A ) 3TJ5 (X-ray 1.99A ) 3TJ6 (X-ray 2.76A ) 3VF0 (X-ray 2.54A ) 4DJ9 (X-ray 2.25A ) 4EHP (X-ray 2.66A ) 4LN2 (X-ray 1.00A ) 4LNP (X-ray 1.41A ) 4PR9 (X-ray 3.20A ) 5L0C (X-ray 3.10A ) 5L0D (X-ray 2.75A ) 5L0F (X-ray 2.76A ) 5L0G (X-ray 3.40A ) 5L0H (X-ray 2.90A ) 5L0I (X-ray 2.45A ) 5L0J (X-ray 4.00A ) 5O2Q (NMR - ) 6FUY (X-ray 3.00A ) 6UPW (EM 2.90A ) 7KTT (EM 4.17A ) 7KTU (EM 4.15A ) 7KTV (EM 4.50A ) 7KTW (EM 4.27A ) |
| DBSNP | rs17853882 rs71579353 rs16931179 rs71579375 rs121917776 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:P12003}; Peripheral membrane protein {ECO:0000250|UniProtKB:P12003}; Cytoplasmic side {ECO:0000250|UniProtKB:P12003}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P12003}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P12003}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P85972}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q64727}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64727}; Cytoplasmic side {ECO:0000250|UniProtKB:Q64727}. Note=Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions. {ECO:0000250|UniProtKB:P12003}. |
| Mouse PG classification | NA |
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