| Gene Information | |
|---|---|
| Gene Name | CYP7A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 504 |
| Protein Names | Cytochrome P450 7A1 (24-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.26) (CYPVII) (Cholesterol 7-alpha-hydroxylase) (Cholesterol 7-alpha-monooxygenase) (EC 1.14.14.23) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000167910 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P22680 |
| Gene Card | CYP7A1 |
| Uniprot ID | P22680 |
| Pfam | PF00067 |
| In ASD | no |
| Allosteric Prediction | yes (0.657642011) |
| Ortholog in Animals | Alpaca_ CYP7A1 ( ortholog_one2one ) Dog_ CYP7A1 ( ortholog_one2one ) GuineaPig_ CYP7A1 ( ortholog_one2one ) Macaque_ CYP7A1 ( ortholog_one2one ) Mouse_ Cyp7a1 ( ortholog_one2one ) Pig_ CYP7A1 ( ortholog_one2one ) Rat_ Cyp7a1 ( ortholog_one2one ) Rabbit_ CYP7A1 ( ortholog_one2one ) |
| Ohnologs | CYP39A1 |
| Paralogs | CYP7B1, CYP39A1 |
| Tissue | liver |
| Tissue Specificity | Detected in liver. {ECO:0000269|PubMed:15796896}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.023983(Mouse);NULL(Rat);0.022222(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3DAX (X-ray 2.15A ) 3SN5 (X-ray 2.75A ) 3V8D (X-ray 1.90A ) |
| DBSNP | rs62621283 rs8192874 rs8192875 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000305|PubMed:11013305, ECO:0000305|PubMed:2384150}; Single-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305|PubMed:11013305, ECO:0000305|PubMed:2384150}; Single-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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