| Gene Information | |
|---|---|
| Gene Name | OAS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 400 |
| Protein Names | 2'-5'-oligoadenylate synthase 1 ((2-5')oligo(A) synthase 1) (2-5A synthase 1) (EC 2.7.7.84) (E18/E16) (p46/p42 OAS) |
| Target Name | 2'-5'-oligoadenylate synthase 1 |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000089127 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P00973 |
| Gene Card | OAS1 |
| Uniprot ID | P00973 |
| Pfam | PF01909; PF10421 |
| In ASD | yes |
| Allosteric Prediction | yes (0.659820122) |
| Ortholog in Animals | Alpaca_ OAS1 ( ortholog_one2one ) Dog_ OAS1 ( ortholog_one2one ) GuineaPig_ OAS1 ( ortholog_one2one ) Macaque_ OAS1 ( ortholog_one2one ) Mouse_ Oas1f ( ortholog_one2many ) Mouse_ Oas1a ( ortholog_one2many ) Mouse_ Oas1b ( ortholog_one2many ) Mouse_ Oas1g ( ortholog_one2many ) Mouse_ Oas1c ( ortholog_one2many ) Mouse_ Oas1e ( ortholog_one2many ) Mouse_ Oas1h ( ortholog_one2many ) Mouse_ Oas1d ( ortholog_one2many ) Pig_ OAS1 ( ortholog_one2one ) Rat_ Oas1a ( ortholog_one2many ) Rat_ Oas1d ( ortholog_one2many ) Rat_ Oas1h ( ortholog_one2many ) Rat_ Oas1k ( ortholog_one2many ) Rat_ Oas1i ( ortholog_one2many ) Rat_ Oas1f ( ortholog_one2many ) Rat_ Oas1e ( ortholog_one2many ) Rabbit_ OAS1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | OAS2, OAS3, OASL |
| Tissue | NA |
| Tissue Specificity | Expressed in lungs. {ECO:0000269|PubMed:34581622}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4IG8 (X-ray 2.70A ) |
| DBSNP | rs1050994 rs4767022 rs1131454 rs1131476 rs35919998 rs1051042 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:3753689, ECO:0000269|PubMed:3754863}. Mitochondrion {ECO:0000269|PubMed:19923450}. Nucleus {ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:3753689}. Microsome {ECO:0000269|PubMed:19923450}. Endoplasmic reticulum {ECO:0000269|PubMed:19923450}. Secreted {ECO:0000250|UniProtKB:Q29599}. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions. {ECO:0000269|PubMed:19923450}.; [Isoform p46]: Note=(Microbial infection) In SARS coronavirus-2/SARS-CoV-2 infected cells, prenylated form localizes to membranous perinuclear structures reminiscent of the endoplasmic reticulum rich in viral dsRNA which are SARS-CoV-2 replicative organelles. {ECO:0000269|PubMed:34581622}.; [Isoform p42]: Note=(Microbial infection) In SARS coronavirus-2/SARS-CoV-2 infected cells, since its not prenylated, is diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication. {ECO:0000269|PubMed:34581622}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |