| Gene Information | |
|---|---|
| Gene Name | CLAPB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 937 |
| Protein Names | AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P63010 |
| Gene Card | AP2B1 |
| Uniprot ID | P63010 |
| Pfam | PF01602; PF02883; PF09066 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in the brain (at protein level). {ECO:0000269|PubMed:23676497}. |
| Pharmacological Animal Models | 0.154324(Chimpanzee);0.119705(Mouse);NULL(Rat);0.048000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1E42 (X-ray 1.70A ) 2G30 (X-ray 1.60A ) 2IV8 (X-ray 2.80A ) 2IV9 (X-ray 1.90A ) 2JKR (X-ray 2.98A ) 2JKT (X-ray 3.40A ) 2VGL (X-ray 2.59A ) 2XA7 (X-ray 3.10A ) 4UQI (X-ray 2.79A ) 5M5R (X-ray 1.76A ) 6QH5 (X-ray 2.56A ) 6QH6 (X-ray 5.00A ) 6QH7 (X-ray 3.40A ) 6URI (X-ray 3.00A ) 6YAE (EM 3.90A ) 6YAF (EM 9.10A ) 6YAH (EM 10.20A ) 6YAI (EM 9.20A ) 7OG1 (X-ray 3.25A ) 7OHO (X-ray 2.88A ) 7OM8 (EM 10.50A ) 7Z5C (EM 4.16A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:14530274}. Membrane, coated pit {ECO:0000269|PubMed:14530274}; Peripheral membrane protein {ECO:0000269|PubMed:14530274}; Cytoplasmic side {ECO:0000269|PubMed:14530274}. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. |
| Mouse PG classification | NA |
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