| Gene Information | |
|---|---|
| Gene Name | PXN |
| Organism | Homo sapiens (Human) |
| Gene Length | 591 |
| Protein Names | Paxillin |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000089159 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P49023 |
| Gene Card | PXN |
| Uniprot ID | P49023 |
| Pfam | PF00412 |
| In ASD | no |
| Allosteric Prediction | yes (0.838208243) |
| Ortholog in Animals | Alpaca_ PXN ( ortholog_one2many ) Dog_ PXN ( ortholog_one2one ) GuineaPig_ PXN ( ortholog_one2one ) Macaque_ PXN ( ortholog_one2one ) Mouse_ Pxn ( ortholog_one2one ) Pig_ PXN ( ortholog_one2one ) Rat_ Pxn ( ortholog_one2one ) Rabbit_ PXN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LPXN, TGFB1I1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1OW6 (X-ray 2.35A ) 1OW7 (X-ray 2.60A ) 1OW8 (X-ray 2.85A ) 2K2R (NMR - ) 2O9V (X-ray 1.63A ) 2VZD (X-ray 2.10A ) 2VZG (X-ray 1.80A ) 2VZI (X-ray 2.20A ) 3GM1 (X-ray 2.95A ) 3PY7 (X-ray 2.29A ) 3RQE (X-ray 2.80A ) 3RQF (X-ray 2.70A ) 3RQG (X-ray 2.50A ) 3U3F (X-ray 3.10A ) 4EDN (X-ray 2.90A ) 4R32 (X-ray 3.70A ) 4XGZ (X-ray 2.50A ) 4XH2 (X-ray 2.00A ) 5UWH (X-ray 2.26A ) 6IUI (X-ray 2.60A ) 6PW8 (X-ray 1.95A ) 6U4M (NMR - ) 6U4N (NMR - ) |
| DBSNP | rs4767884 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20489202}. Cell junction, focal adhesion {ECO:0000269|PubMed:20489202, ECO:0000269|PubMed:23128389}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q8VI36}. Note=Colocalizes with integrins at the cell periphery. Colocalize with PXN to membrane ruffles and the leading edge of migrating cells (PubMed:23128389). {ECO:0000250, ECO:0000269|PubMed:23128389}. |
| Mouse PG classification | NA |
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